Double Biologic Therapy for Refractory Stricturing Crohn's Disease: A Successful Case of Deep Remission with Ustekinumab and Vedolizumab

被引:14
作者
Elmoursi, Ahmed [1 ]
Barrett, Terrence A. [1 ]
Perry, Courtney [1 ]
机构
[1] Univ Kentucky, Dept Internal Med, Div Gastroenterol, 800 Rose St,MN649, Lexington, KY 40536 USA
基金
美国国家卫生研究院;
关键词
double biologic therapy (DBT); vedolizumab; ustekinumab; stricture; Crohn's disease;
D O I
10.1093/ibd/izaa092
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Stricturing Crohn's disease (CD) is a severe phenotype that presents unique challenges to therapeutic management. Emerging literature suggests that anti-TNF monoclonal antibody (mAb) therapies are inadequate for preventing progression to stricture. We hereby present a case of a patient with refractory CD who required multiple surgical resections despite several anti-TNF treatment regimens. Subsequent surgical complications were avoided after changing to combination vedolizumab and ustekinumab therapies every 4 weeks. This case argues for a tailored approach to CD therapy based on disease phenotype and demonstrates that combination therapy with ustekinumab and vedolizumab is a viable option for patients with stricturing disease.
引用
收藏
页码:E62 / E63
页数:2
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