Histological classification of melasma with reflectance confocal microscopy: a pilot study in Chinese patients

被引：34

作者：

Liu, Huaxu ^{[1
]}

Lin, Yan ^{[1
]}

Nie, Xiaojuan ^{[1
]}

Chen, Shengli ^{[1
]}

Chen, Xuechao ^{[1
]}

Shi, Benqing ^{[1
]}

Tian, Hongqing ^{[1
]}

Shi, Zhongxiang ^{[1
]}

Yu, Meiling ^{[1
]}

Zhang, Dizhan ^{[1
]}

Yang, Baoqi ^{[1
]}

Wang, Guangjin ^{[1
]}

Wu, Mei ^{[1
]}

Zhang, Furen ^{[1
]}

机构：

[1] Shandong Acad Med Sci, Shandong Prov Inst Dermatol & Venereol, Jinan 250022, Shandong, Peoples R China

来源：

SKIN RESEARCH AND TECHNOLOGY | 2011年 / 17卷 / 04期

关键词：

melasma; classification; reflectance confocal microscopy; in vivo; histopathology; SCANNING LASER MICROSCOPY; IN-VIVO; HUMAN SKIN; LIGHT;

D O I：

10.1111/j.1600-0846.2011.00517.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Objective: To investigate the histological classification of melasma with reflectance confocal microscopy (RCM) in vivo. Methods: Two hundred and ten cases with facial melasma lesions were enrolled. After informed consent, the target melasma lesion of 10 patients were imaged with RCM and then biopsied as well. Under the RCM scanning, the distribution of the melanin determined the histological types, and then, the results of RCM images were compared with those of the histopathology. The other 200 cases were tested only with RCM. Results: For the 10 cases imaged and biopsied, compared with that of the perilesional normal skin, the amount of melanin was significantly increased in the epidermis in all lesions under RCM, while three cases also found melanin in the dermis. Thus, seven of the 10 patients were categorized as the epidermal type while the other three as mixed ones, and the results were well correlated with those of the histopathology. Of the other 200 patients, 143 cases 71.5%) were categorized as the epidermal type while the other 57 (28.5%) cases as mixed ones. Limitations: If more melasma cases are biopsied, the data will be more convincing. Conclusion: RCM in vivo analysis shows complete coherence with histopathology results, which could be an alternative for the classification of melasma, and based on the results of RCM imaging, melasma is classified into two major types: the epidermal type and mixed type.

引用

页码：398 / 403

页数：6

共 21 条

[1] Reflectance confocal microscopy of pigmented basal cell carcinoma [J].