Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study

被引:161
作者
Siderowf, Andrew [1 ]
Jennings, Danna [2 ]
Eberly, Shirley [3 ]
Oakes, David [3 ]
Hawkins, Keith A. [4 ]
Ascherio, Albert [5 ]
Stern, Matthew B. [1 ]
Marek, Kenneth [2 ]
机构
[1] Univ Penn, Dept Neurol, Perelman Sch Med, Parkinsons Dis & Movement Disorders Ctr, Philadelphia, PA 19104 USA
[2] Inst Neurodegenerat Disorders, New Haven, CT USA
[3] Univ Rochester, Sch Med, Dept Biostat, Rochester, NY USA
[4] Yale Univ, Dept Psychol, New Haven, CT 06520 USA
[5] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA
关键词
Parkinson's disease; olfaction; early detection; nonmotor features; DISEASE; DYSFUNCTION; IDENTIFICATION; ASSOCIATION; QUESTIONNAIRE; RELIABILITY; DEPRESSION; RELATIVES; SYSTEM; STAGE;
D O I
10.1002/mds.24892
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
To test the association between impaired olfaction and other prodromal features of PD in the Parkinson At-Risk Syndrome Study. The onset of olfactory dysfunction in PD typically precedes motor features, suggesting that olfactory testing could be used as a screening test. A combined strategy that uses other prodromal nonmotor features, along with olfactory testing, may be more efficient than hyposmia alone for detecting the risk of PD. Individuals with no neurological diagnosis completed a mail survey, including the 40-item University of Pennsylvania Smell Identification Test, and questions on prodromal features of PD. The frequency of reported nonmotor features was compared across individuals with and without hyposmia. A total of 4,999 subjects completed and returned the survey and smell test. Of these, 669 were at or below the 15th percentile based on age and gender, indicating hyposmia. Hyposmics were significantly more likely to endorse nonmotor features, including anxiety and depression, constipation, and rapid eye movement sleep behavior disorder symptoms, and to report changes in motor function. Twenty-six percent of subjects with combinations of four or more nonmotor features were hyposmic, compared to 12% for those reporting three or fewer nonmotor features (P < 0.0001). Hyposmia is associated with other nonmotor features of PD in undiagnosed individuals. Further assessment of hyposmic subjects using more specific markers for degeneration, such as dopamine transporter imaging, will evaluate whether combining hyposmia and other nonmotor features is useful in assessing the risk of future neurodegeneration. (c) 2012 Movement Disorder Society (c) 2012 Movement Disorder Society
引用
收藏
页码:406 / 412
页数:7
相关论文
共 42 条
  • [21] Abnormal performance on the PD test battery by asymptomatic first-degree relatives
    Montgomery, EB
    Baker, KB
    Lyons, K
    Koller, WC
    [J]. NEUROLOGY, 1999, 52 (04) : 757 - 762
  • [22] CIGARETTE-SMOKING AND PROTECTION FROM PARKINSONS-DISEASE - FALSE ASSOCIATION OR ETIOLOGIC CLUE
    MORENS, DM
    GRANDINETTI, A
    REED, D
    WHITE, LR
    ROSS, GW
    [J]. NEUROLOGY, 1995, 45 (06) : 1041 - 1051
  • [23] Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F] dopa PET
    Morrish, PK
    Rakshi, JS
    Bailey, DL
    Sawle, GV
    Brooks, DJ
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 64 (03) : 314 - 319
  • [24] Idiopathic hyposmia as a preclinical sign of Parkinson's disease
    Ponsen, MM
    Stoffers, D
    Booij, J
    van Eck-Smit, BLF
    Wolters, EC
    Berendse, HW
    [J]. ANNALS OF NEUROLOGY, 2004, 56 (02) : 173 - 181
  • [25] Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder
    Postuma, R. B.
    Gagnon, J. F.
    Vendette, M.
    Fantini, M. L.
    Massicotte-Marquez, J.
    Montplaisir, J.
    [J]. NEUROLOGY, 2009, 72 (15) : 1296 - 1300
  • [26] Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder
    Postuma, RB
    Lang, AE
    Massicotte-Marquez, M
    Montplaisir, J
    [J]. NEUROLOGY, 2006, 66 (06) : 845 - 851
  • [27] Validation of a mail questionnaire for parkinsonism in two languages (German and Italian)
    Pramstaller, PP
    Falk, M
    Schoenhuber, R
    Poewe, W
    [J]. JOURNAL OF NEUROLOGY, 1999, 246 (02) : 79 - 86
  • [28] RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
  • [29] L-Type Calcium Channel Blockers and Parkinson Disease in Denmark
    Ritz, Beate
    Rhodes, Shannon L.
    Qian, Lei
    Schernhammer, Eva
    Olsen, Jorgen H.
    Friis, Soren
    [J]. ANNALS OF NEUROLOGY, 2010, 67 (05) : 600 - 606
  • [30] Association of olfactory dysfunction with risk for future Parkinson's disease
    Ross, G. Webster
    Petrovitch, Helen
    Abbott, Robert D.
    Tanner, Caroline M.
    Popper, Jordan
    Masaki, Kamal
    Launer, Lenore
    White, Lon R.
    [J]. ANNALS OF NEUROLOGY, 2008, 63 (02) : 167 - 173