How to Approach a Patient With Limited Stage Hodgkin Lymphoma Who Remains PET Positive at the End of Chemotherapy: Radiation Therapy?

被引：1

作者：

Ozuah, Nmazuo W. ^{[1
]}

LaCasce, Ann S. ^{[2
]}

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02215 USA

[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2017年 / 17卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Autologous stem cell transplant; Early stage Hodgkin lymphoma; Positron emission tomography; Radiotherapy; POSITRON-EMISSION-TOMOGRAPHY; INVOLVED-FIELD RADIOTHERAPY; STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; EVENT-FREE SURVIVAL; FDG-PET; OF-TREATMENT; INTERNATIONAL WORKSHOP; RESPONSE CRITERIA;

D O I：

10.1016/j.clml.2017.06.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The use of 18-F fluorodeoxyglucose (FDG) positron emission tomography (PET) with computed tomography has emerged as a crucial tool for response-adapted therapy in Hodgkin lymphoma (HL). Although more studies have focused on the predictive value of an interim or early PET obtained after 2 cycles of chemotherapy, there are indications that the end of therapy PET might even be more predictive of outcome. The optimal treatment of patients with limited stage HL who are PET-positive after chemotherapy is unknown. Here we review the prognostic significance of end of treatment PET in early stage HL, the role of consolidative radiotherapy in patients who have FDG-PET avidity at the end of chemotherapy, and discuss the place of salvage chemotherapy and autologous transplantation in these patients. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：710 / 715

页数：6

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