Synthesis of imidazo[1,2-a]pyridines as antiviral agents

被引：217

作者：

Gueiffier, A

Mavel, S

Lhassani, M

Elhakmaoui, A

Snoeck, R

Andrei, G

Chavignon, O

Teulade, JC

Witvrouw, M

Balzarini, J

De Clercq, E

Chapat, JP

机构：

[1] Univ Tours, Fac Pharm, Chim Therapeut Lab, F-37200 Tours, France

[2] EA Pharmacochim & Biomol, Lab Chim Organ Pharmaceut, F-34060 Montpellier, France

[3] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

[4] UFR Pharm, Grp Rech Pharmacochim, Lab Chim Organ Pharmaceut, F-63001 Clermont Ferrand, France

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 25期

关键词：

D O I：

10.1021/jm981051y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.

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收藏

页码：5108 / 5112

页数：5

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