Understanding the dynamics of imipenem-resistant Acinetobacter baumannii lineages within Portugal

被引：41
作者：
Grosso, F. [1 ]
Quinteira, S. [1 ]
Peixe, L. [1 ]
机构：
[1] Univ Porto, Microbiol Lab, Fac Farm, REQUIMTE, P-4050047 Oporto, Portugal
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2011年 / 17卷 / 08期
关键词：
bla(OXA-51)-like; carbapenemase; multilocus sequence typing; pulsed-field gel electrophoresis type; sequence groups; MULTIPLEX PCR; EXPRESSION; GENE; DISSEMINATION; BLA(OXA-23); EMERGENCE; STRAINS; OXA-40; CLONE;
D O I：
10.1111/j.1469-0691.2011.03469.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A recent collection of 213 imipenem-resistant Acinetobacter baumannii (IRAB) clinical isolates was characterized for the presence of acquired carbapenem-hydrolysing class D beta-lactamases (CHDLs) and clonality. A population structure analysis of IRAB was also conducted, with five molecular typing methods. Three main clusters, each one associated with a specific CHDL, were observed with multilocus sequence typing. Overall, our results suggest a switch in the dominant clone, with sequence type (ST) 92, carrying bla(OXA-23) (63.4%), replacing the closely related ST98, carrying bla(OXA-24/40) (22%). In addition, ST103, an independent lineage, was associated with bla(OXA-58)-carrying isolates (14.6%).
引用
收藏
页码：1275 / 1279
页数：6
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