Evidence for a heritable predisposition to death due to influenza

被引:109
作者
Albright, Frederick S. [4 ]
Orlando, Patricia [4 ]
Pavia, Andrew T. [2 ]
Jackson, George G. [3 ]
Albright, Lisa A. Cannon [1 ]
机构
[1] Univ Utah, Sch Med, Dept Biomed Informat, Salt Lake City, UT 84108 USA
[2] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT 84108 USA
[3] Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT 84108 USA
[4] Univ Utah, Coll Pharm, Dept Pharmacotherapy, Salt Lake City, UT 84112 USA
关键词
D O I
10.1086/524064
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Animal model studies and human epidemiological studies have shown that some infectious diseases develop primarily in individuals with an inherited predisposition. A heritable contribution to the development of severe influenza virus infection (i.e., that which results in death) has not previously been hypothesized or tested. Evidence for a heritable contribution to death due to influenza was examined using a resource consisting of a genealogy of the Utah population linked to death certificates in Utah over a period of 100 years. The relative risks of death due to influenza were estimated for the relatives of 4855 individuals who died of influenza. Both close and distant relatives of individuals who died of influenza were shown to have a significantly increased risk of dying of influenza, consistent with a combination of shared exposure and genetic effects. These data provide strong support for a heritable contribution to predisposition to death due to influenza.
引用
收藏
页码:18 / 24
页数:7
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