pH and Redox Dual Stimuli-Responsive Injectable Hydrogels Based on Carboxymethyl Cellulose Derivatives

被引：35

作者：

Shen, Yueqin ^{[1
]}

Li, Xian ^{[1
,2
]}

Huang, Yawen ^{[2
]}

Chang, Guanjun ^{[2
]}

Cao, Ke ^{[2
]}

Yang, Junxiao ^{[2
]}

Zhang, Renyi ^{[1
]}

Sheng, Xueying ^{[1
]}

Ye, Xu ^{[1
]}

机构：

[1] Southwest Univ Sci & Technol, Sch Mat Sci & Engn, Mianyang 621010, Peoples R China

[2] Southwest Univ Sci & Technol, State Key Lab Cultivat Base Nonmet Composites & F, Mianyang 621010, Peoples R China

来源：

MACROMOLECULAR RESEARCH | 2016年 / 24卷 / 07期

关键词：

carboxymethyl cellulose; injectable hydrogel; pH responsive; redox responsive; CROSS-LINKED MICELLES; HYALURONIC-ACID; PROTEIN DELIVERY; BIOMEDICAL APPLICATIONS; TRIGGERED RELEASE; GEL PROPERTIES; DRUG-RELEASE; SYSTEM; SCAFFOLDS;

D O I：

10.1007/s13233-016-4077-6

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

pH and redox dual stimuli-responsive injectable hydrogels were prepared by cross-linking oxidized carboxymethyl cellulose (oxi-CMC) with 3,3'-dithiobis (propionohydrazide) (DTP) via Schiff base reaction under physiological condition. The hydrogels showed good performance such as tunable gelling time, appropriate rheology properties, high swelling ratio and low degradation rate. In vitro release studies confirmed that bovine serum albumin (BSA) as a model drug exhibited a sustainable release at pH 7.4 and an accelerated release under a lower pH 5.0 and/or reducing environments. The results signified that oxi-CMC/DTP hydrogels could be an attractive candidate for drug delivery system, tissue engineering or cell scaffold materials.

引用

页码：602 / 608

页数：7

共 37 条

[1] Novel poly(L-lactic acid)/hyaluronic acid macroporous hybrid scaffolds: Characterization and assessment of cytotoxicity [J].

Antunes, J. C. ;

Oliveira, J. M. ;

Reis, R. L. ;

Soria, J. M. ;

Gomez-Ribelles, J. L. ;

Mano, J. F. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2010, 94A (03) :856-869

[2] Injectable biodegradable hydrogels: progress and challenges [J].

Bae, Ki Hyun ;

Wang, Li-Shan ;

Kurisawa, Motoichi .

JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (40) :5371-5388

[3] Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds [J].

Balakrishnan, B ;

Jayakrishnan, A .

BIOMATERIALS, 2005, 26 (18) :3941-3951

[4] Advantages of cross-linked versus linear hyaluronic acid for semisolid skin delivery systems [J].

Berko, Szilvia ;

Maroda, Monika ;

Bodnar, Magdolna ;

Eros, Gabor ;

Hartmann, Petra ;

Szentner, Kinga ;

Szabo-Revesz, Piroska ;

Kemeny, Lajos ;

Borbely, Janos ;

Csanyi, Erzsebet .

EUROPEAN POLYMER JOURNAL, 2013, 49 (09) :2511-2517

[5] Hydrogels for protein delivery in tissue engineering [J].

Censi, Roberta ;

Di Martino, Piera ;

Vermonden, Tina ;

Hennink, Wim E. .

JOURNAL OF CONTROLLED RELEASE, 2012, 161 (02) :680-692

[6] Holy Basil (Ocimum sanctum Linn.) Essential Oil Delivery to Swine Gastrointestinal Tract Using Gelatin Microcapsules Coated with Aluminum Carboxymethyl Cellulose and Beeswax [J].

Chitprasert, Pakamon ;

Sutaphanit, Polin .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, 62 (52) :12641-12648

[7] Dynamic combinatorial chemistry [J].

Corbett, Peter T. ;

Leclaire, Julien ;

Vial, Laurent ;

West, Kevin R. ;

Wietor, Jean-Luc ;

Sanders, Jeremy K. M. ;

Otto, Sijbren .

CHEMICAL REVIEWS, 2006, 106 (09) :3652-3711

[8] Dynamic Hydrogels with an Environmental Adaptive Self-Healing Ability and Dual Responsive Sol-Gel Transitions [J].

Deng, Guohua ;

Li, Fuya ;

Yu, Hongxia ;

Liu, Fuyong ;

Liu, Chenyang ;

Sun, Weixiang ;

Jiang, Huanfeng ;

Chen, Yongming .

ACS MACRO LETTERS, 2012, 1 (02) :275-279

[9] Protein-reactive, thermoresponsive copolymers with high flexibility and biodegradability [J].

Guan, Jianjun ;

Hong, Yi ;

Ma, Zuwei ;

Wagner, William R. .

BIOMACROMOLECULES, 2008, 9 (04) :1283-1292

[10] Redox- and pH-Responsive Cysteamine-Modified Poly(aspartic acid) Showing a Reversible SolGel Transition [J].

Gyarmati, Benjamin ;

Vajna, Balazs ;

Nemethy, Arpad ;

Laszlo, Krisztina ;

Szilagyi, Andras .

MACROMOLECULAR BIOSCIENCE, 2013, 13 (05) :633-640

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