Crystal structure of (E)-7-fluoro-2-(3-fluorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one, C17H12F2O1

被引：2
作者：
Song, Jia [1 ]
Feng-Lan Zhao [1 ]
Qi-bao Wang [2 ]
Qing-Guo Meng [1 ]
机构：
[1] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai, Peoples R China
[2] Jining Med Univ, Sch Biol Sci, 669 Xueyuan Rd, Rizhao 276800, Shandong, Peoples R China
来源：
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES | 2022年 / 237卷 / 01期
基金：
中国国家自然科学基金;
关键词：
ANTIINFLAMMATORY ACTIVITY; DERIVATIVES; AGENTS; 3,5-BIS(ARYLIDENE)-4-PIPERIDONES; INHIBITORS;
D O I：
10.1515/ncrs-2021-0392
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
C17H12F2O1, monoclinic, P (1) over bar (no. 2), a = 7.3832(8) angstrom, b = 8.6467(9) angstrom, c = 11.3278(11) angstrom, alpha = 87.633(8)degrees, beta = 88.022(8)degrees, gamma = 65.364(10)degrees, V = 654.88(13) angstrom(3), Z = 2, R-gt(F) = 0.0369, wR(ref)(F-2) = 0.0987, T = 293(2) K.
引用
收藏
页码：55 / 57
页数：3
相关论文
共 17 条
[1]   Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke [J].
Gao, Cheng-Long ;
Hou, Gui-Ge ;
Liu, Jin ;
Ru, Tong ;
Xu, Ya-Zhou ;
Zhao, Shun-Yi ;
Ye, Hui ;
Zhang, Lu-Yong ;
Chen, Kai-Xian ;
Guo, Yue-Wei ;
Pang, Tao ;
Li, Xu-Wen .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (06) :2429-2439
[2]   Role of Microglia in CNS Autoimmunity [J].
Goldmann, Tobias ;
Prinz, Marco .
CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2013,
[3]   N-phenylsulfony1-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-κB inhibitors in hepatic carcinoma cell lines [J].
Li, Ning ;
Xin, Wen-Yu ;
Yao, Bin-Rong ;
Cong, Wei ;
Wang, Chun-Hua ;
Hou, Gui-Ge .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 155 :531-544
[4]   Novel dissymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo [J].
Li, Ning ;
Xin, Wen-Yu ;
Yao, Bin-Rong ;
Wang, Chun-Hua ;
Cong, Wei ;
Zhao, Feng ;
Li, Hong-Juan ;
Hou, Yun ;
Meng, Qing-Guo ;
Hou, Gui-Ge .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 147 :21-33
[5]   Synthesis, crystal structure and activity evaluation of novel 3,4-dihydro-1-benzoxepin-5(2H)-one derivatives as protein-tyrosine kinase (PTK) inhibitors [J].
Li, Ning ;
Yao, Binrong ;
Wang, Chunhua ;
Meng, Qingguo ;
Hou, Guige .
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2017, 73 :1003-+
[6]   Crystal structure of (E)-7-methoxy-2((5-methoxypyridin-3-yl)methylene)-3,4-dihydronaphthalen-1(2H)-one, C18H17NO3 [J].
Luan, Ming-Zhu ;
Meng, Qing-Guo .
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2021, 236 (02) :387-389
[7]  
Rigaku OD, 2017, CRYSALIS PRO
[8]  
Sheldrick GM, 2015, ACTA CRYSTALLOGR C, V71, P3, DOI [10.1107/S2053273314026370, 10.1107/S2053229614024218, 10.1107/S0108767307043930]
[9]   Inflammation in CNS neurodegenerative diseases [J].
Stephenson, Jodie ;
Nutma, Erik ;
van der Valk, Paul ;
Amor, Sandra .
IMMUNOLOGY, 2018, 154 (02) :204-219
[10]   Potential anti-neuroinflammatory NF-kB inhibitors based on 3,4-dihydronaphthalen-1(2H)-one derivatives [J].
Sun, Yue ;
Zhou, Yan-Qiu ;
Liu, Yin-Kai ;
Zhang, Hong-Qin ;
Hou, Gui-Ge ;
Meng, Qing-Guo ;
Hou, Yun .
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 35 (01) :1631-1640
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