Protein tyrosine phosphatases: Properties and biological functions

被引:19
作者
Aoyama, H [1 ]
Silva, TMA [1 ]
Miranda, MA [1 ]
Ferreira, CV [1 ]
机构
[1] Univ Estadual Campinas, Dept Bioquim, Inst Biol, BR-13083970 Campinas, SP, Brazil
来源
QUIMICA NOVA | 2003年 / 26卷 / 06期
关键词
protein tyrosine phosphatases; signal transduction; biological function;
D O I
10.1590/S0100-40422003000600019
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Protein phosphorylation-dephosphorylation catalyzed by the opposing and dynamic action of protein kinases and phosphatases probably, is the most crucial chemical reaction taking place in living organisms. Protein phosphatases are classified according to their substrate specificity and sensitivity to inhibitory or activator agents, into two families of protein phosphatases: serine/threonine phosphatases and tyrosiric phosphatases (PTPs). PTPs can be divided into 3 groups: tyrosine specific phosphatases, dual and low molecular weight phosphatases. The role of tyrosine phosphorylation in mitogenic signaling is well documented, and one would predict that vanadate, pervanadate and other oxidant agents (protein tyrosine phosphatase inhibitors) may act as a growth stimulator.
引用
收藏
页码:896 / 900
页数:5
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