Synthesis of Patent Blue derivatized hydrophilic dendrons dedicated to sentinel node detection in breast cancer

被引：8

作者：

Kueny-Stotz, Marie ^{[1
]}

Mamlouk-Chaouachi, Hind ^{[1
]}

Felder-Flesch, Delphine ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, IPCMS, UMR 7504, F-67034 Strasbourg 2, France

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 22期

关键词：

Sulfonamide; Phosphonate; Dendronized nanoparticle; Breast cancer; Patent Blue; IRON-OXIDE NANOPARTICLES; LYMPH-NODE; LOCALIZATION; DYE;

D O I：

10.1016/j.tetlet.2011.03.144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the last decade, methods for the precise localization of sentinel lymph node (SLN) have drawn tremendous attention by oncology surgeons and researchers in the field of medical diagnosis. The accurate identification and characterization of lymph nodes by imaging has important therapeutic and prognostic significance in patients with newly diagnosed cancers. The SLN is the first lymph node that receives lymphatic drainage from the site of a primary tumor. Two biocompatible dendronized phosphonates, one bearing a Patent Blue (PB VF) dye at its periphery, where synthesized. Indeed, such a blue dye is currently injected to label the lymph node system for its per-operative detection. Therefore, developing chemistry of Patent Blue VF to optimize early diagnosis is of great current interest. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2906 / 2909

页数：4

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