Gut Microbiota, Leaky Gut, and Autoimmune Diseases

被引：96

作者：

Christovich, Anna ^{[1
]}

Luo, Xin M. ^{[2
]}

机构：

[1] Virginia Tech, Dept Biol Syst Engn, Blacksburg, VA USA

[2] Virginia Tech, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

gut microbiota; leaky gut; systemic lupus erythematosus; type; 1; diabetes; multiple sclerosis; T-CELLS; INTESTINAL MICROBIOTA; MULTIPLE-SCLEROSIS; METABOLITES; MICE; DIFFERENTIATION; SUSCEPTIBILITY; MECHANISMS; EXPRESSION; PREVENTION;

D O I：

10.3389/fimmu.2022.946248

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

With the rising prevalence of autoimmune diseases, the role of the environment, specifically the gut microbiota, in disease development has grown to be a major area of study. Recent advances show a relationship and possible cause and effect between the gut microbiota and the initiation or exacerbation of autoimmune diseases. Furthermore, microbial dysbiosis and leaky gut are frequent phenomena in both human autoimmune diseases and the murine autoimmunity models. This review will focus on literature in recent years concerning the gut microbiota and leaky gut in relation to the autoimmune diseases, including systemic lupus erythematosus, type 1 diabetes, and multiple sclerosis.

引用

页数：7

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