Clinical efficacy and CT perfusion of puerarin combined with naloxone in the treatment of traumatic cerebral infarction

被引:11
作者
Li Lubo [1 ]
Nie Sulin [1 ]
Dong Zhimei [1 ]
Ning Houfa [2 ]
机构
[1] Changyi Peoples Hosp, Magnet Resonance Room, Changyi, Peoples R China
[2] Weifang Med Coll, Affiliated Hosp, Intervent Room, Weifang, Peoples R China
关键词
Puerarin; naloxone; cerebral infarction; traumatic; BUCCAL MISOPROSTOL; CIPROFLOXACIN DERIVATIVES; ANTIBACTERIAL ACTIVITY; OXIDATIVE STRESS; MEDICAL ABORTION; MIFEPRISTONE; DESIGN; COHORT;
D O I
10.36721/PJPS.2020.33.1.SP.423-428.1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Puerarin is an important active ingredient of Radix puerariae. Puerarin is an isoflavone compound Z clinical and basic research proves that S. puerarin can increase cerebral circulation blood flow; increase cerebral perfusion; reduce blood viscosity and improve microcirculation. The present research was conducted to observe the clinical efficacy of puerarin combined with naloxone in the treatment of traumatic cerebral infarction (TCI). Methods 52 patients with TCI were randomly divided into two groups. The treatment group was treated with puerarin and naloxone and the control group was treated with conventional therapy. Results: The total effective rate was 82% in the treatment group, which was better than 61% in the control group. The difference was statistically significant (p<0.05). The efficacy of simple TCI in both groups was significantly better than that of TCI with brain contusion; the effect of intracranial hemorrhage and the effect of TCI alone in the two groups; the treatment group was significantly better than the control group (p<0.05). Conclusion: The combination of puerarin and naloxone in the treatment of TCI can improve the curative effect.
引用
收藏
页码:423 / 428
页数:6
相关论文
共 35 条
[1]   Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols [J].
Ajami, Marjan ;
Pazoki-Toroudi, Hamidreza ;
Amani, Hamed ;
Nabavi, Seyed Fazel ;
Braidy, Nady ;
Vacca, Rosa Anna ;
Atanasov, Atanas Georgiev ;
Mocan, Andrei ;
Nabavi, Seyed Mohammad .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2017, 73 :39-47
[2]  
[Anonymous], 2016, NW J INT LAW BUSINES
[3]   Oxidative stress versus antioxidant defenses in patients with acute myocardial infarction [J].
Bagatini, Margarete Dulce ;
Martins, Caroline Curry ;
Battisti, Vanessa ;
Gasparetto, Diogo ;
da Rosa, Cintia Saydelles ;
Spanevello, Roselia Maria ;
Ahmed, Mushtaq ;
Schmatz, Roberta ;
Chitolina Schetinger, Maria Rosa ;
Morsch, Vera Maria .
HEART AND VESSELS, 2011, 26 (01) :55-63
[4]   Design of Ciprofloxacin Derivatives that Inhibit Growth of Methicillin Resistant Staphylococcus aureus (MRSA) and Methicillin Susceptible Staphylococcus aureus (MSSA) [J].
Bartzatt, Ronald ;
Cirillo, Suat L. G. ;
Cirillo, Jeffrey D. .
MEDICINAL CHEMISTRY, 2010, 6 (02) :51-56
[5]   Beyond conventional antibiotics - New directions for combination products to combat biofilm [J].
Bayramov, Danir Fanisovich ;
Neff, Jennifer Ann .
ADVANCED DRUG DELIVERY REVIEWS, 2017, 112 :48-60
[6]  
López LB, 2018, ARCH LATINOAM NUTR, V68, P190
[7]   Microwave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeleton [J].
Ceylan, Sule ;
Bayrak, Hacer ;
Ozdemir, Serap Basoglu ;
Uygun, Yildiz ;
Mermer, Arif ;
Demirbas, Neslihan ;
Ulker, Serdar .
HETEROCYCLIC COMMUNICATIONS, 2016, 22 (04) :229-237
[8]   Mifepristone With Buccal Misoprostol for Medical Abortion A Systematic Review [J].
Chen, Melissa J. ;
Creinin, Mitchell D. .
OBSTETRICS AND GYNECOLOGY, 2015, 126 (01) :12-21
[9]   Naringenin protects cardiac hypercholesterolemia-induced oxidative stress and subsequent necroptosis in rats [J].
Chtourou, Yassine ;
Ben Slima, Ahlem ;
Makni, Mohamed ;
Gdoura, Radhouane ;
Fetoui, Hamadi .
PHARMACOLOGICAL REPORTS, 2015, 67 (06) :1090-1097
[10]   Studies on the antimicrobial properties of N-acylated ciprofloxacins [J].
Cormier, Ryan ;
Burda, Whittney N. ;
Harrington, Lacey ;
Edlinger, Jordan ;
Kodigepalli, Karthik M. ;
Thomas, John ;
Kapolka, Rebecca ;
Roma, Glen ;
Anderson, Burt E. ;
Turos, Edward ;
Shaw, Lindsey N. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (20) :6513-6520