Synthesis and antiproliferative activity of some thiazolylbenzimidazole-4,7-diones

被引：35

作者：

Garuti, L

Roberti, M

Pession, A

Leoncini, E

Hrelia, S

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

[2] Univ Bologna, Dept Expt Pathol, Bologna, Italy

[3] Univ Bologna, Dept Biochem G Morozzi, I-40126 Bologna, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(01)00639-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some thiazolylbenzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Compounds 2d and 2e show a very good activity on K562 cells, whereas compounds 2a and 2b are active on SW620 cells. The importance of the methoxy group on the quinone moiety is confirmed and the function at 4-position of the thiazole ring plays a determining role for the activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：3147 / 3149

页数：3

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