Chitosan/carboxymethylcellulose-stabilized poly(lactide-co-glycolide) particles as bio-based drug delivery carriers

被引:29
作者
Inphonlek, Supharat [1 ]
Sunintaboon, Panya [1 ]
Leonard, Michele [2 ]
Durand, Alain [2 ]
机构
[1] Mahidol Univ, Dept Chem, Fac Sci, Rama 6 Rd, Bangkok 10400, Thailand
[2] Univ Lorraine, CNRS, LCPM, UMR 7375, F-54000 Nancy, France
关键词
Chitosan; Carboxymethylcellulose; Polyelectrolyte complex; Suspension; Encapsulation; Release kinetics; CARBOXYMETHYL CELLULOSE; PLGA NANOPARTICLES; CHITOSAN; CURCUMIN; ENCAPSULATION; RELEASE; WATER; PH; CYTOTOXICITY; EMULSIONS;
D O I
10.1016/j.carbpol.2020.116417
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Poly(lactide-co-glycolide) (PLGA) colloidal particles stabilized by complexes of two oppositely charged poly-saccharides, chitosan (cationic, CS) and sodium carboxymethylcellulose (anionic, NaCMC), were fabricated. Dichloromethane containing dissolved PLGA was first emulsi fied in an aqueous phase containing mixtures of CS and NaCMC. Evaporation of dichloromethane from the resulting emulsion led to CS/NaCMC-covered-PLGA particles. CS and NaCMC contents a ffected the short-term stability of PLGA particles and also their intrinsic characteristics. The particles displayed pH-dependent characteristic. Zeta potential varied from +54 to -50 mV when pH was varied from 3 to 10. CS/NaCMC-covered-PLGA particles showed colloidal stability, over a wider pH range as compared to CS-covered-PLGA particles. Curcumin, a model hydrophobic drug, was encapsulated into the particles up to 10 wt% of PLGA. The CS/NaCMC-covered-PLGA particles loaded with curcumin showed delayed release in mildly acidic conditions and faster release in neutral and basic conditions. Cytotoxicity ex-periments were carried out with human colorectal carcinoma cells.
引用
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页数:12
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