Chitosan/carboxymethylcellulose-stabilized poly(lactide-co-glycolide) particles as bio-based drug delivery carriers

被引：31

作者：

Inphonlek, Supharat ^{[1
]}

Sunintaboon, Panya ^{[1
]}

Leonard, Michele ^{[2
]}

Durand, Alain ^{[2
]}

机构：

[1] Mahidol Univ, Dept Chem, Fac Sci, Rama 6 Rd, Bangkok 10400, Thailand

[2] Univ Lorraine, CNRS, LCPM, UMR 7375, F-54000 Nancy, France

来源：

CARBOHYDRATE POLYMERS | 2020年 / 242卷

关键词：

Chitosan; Carboxymethylcellulose; Polyelectrolyte complex; Suspension; Encapsulation; Release kinetics; CARBOXYMETHYL CELLULOSE; PLGA NANOPARTICLES; CHITOSAN; CURCUMIN; ENCAPSULATION; RELEASE; WATER; PH; CYTOTOXICITY; EMULSIONS;

D O I：

10.1016/j.carbpol.2020.116417

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Poly(lactide-co-glycolide) (PLGA) colloidal particles stabilized by complexes of two oppositely charged poly-saccharides, chitosan (cationic, CS) and sodium carboxymethylcellulose (anionic, NaCMC), were fabricated. Dichloromethane containing dissolved PLGA was first emulsi fied in an aqueous phase containing mixtures of CS and NaCMC. Evaporation of dichloromethane from the resulting emulsion led to CS/NaCMC-covered-PLGA particles. CS and NaCMC contents a ffected the short-term stability of PLGA particles and also their intrinsic characteristics. The particles displayed pH-dependent characteristic. Zeta potential varied from +54 to -50 mV when pH was varied from 3 to 10. CS/NaCMC-covered-PLGA particles showed colloidal stability, over a wider pH range as compared to CS-covered-PLGA particles. Curcumin, a model hydrophobic drug, was encapsulated into the particles up to 10 wt% of PLGA. The CS/NaCMC-covered-PLGA particles loaded with curcumin showed delayed release in mildly acidic conditions and faster release in neutral and basic conditions. Cytotoxicity ex-periments were carried out with human colorectal carcinoma cells.

引用

页数：12

共 53 条

[11] Evaluation of pH- responsive poly(styrene-co-maleic acid) copolymer nanoparticles for the encapsulation and pH- dependent release of ketoprofen and tocopherol model drugs [J].

Deak, Agota ;

Sebok, Daniel ;

Csapo, Edit ;

Berczi, Alajos ;

Dekany, Imre ;

Zimanyi, Laszlo ;

Janovak, Laszlo .

EUROPEAN POLYMER JOURNAL, 2019, 114 :361-368

[12] Gemcitabine and Antisense-microRNA Co-encapsulated PLGA-PEG Polymer Nanoparticles for Hepatocellular Carcinoma Therapy [J].

Devulapally, Rammohan ;

Foygel, Kira ;

Sekar, Thillai V. ;

Willmann, Juergen K. ;

Paulmurugan, Ramasamy .

ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (49) :33412-33422

[13] Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics [J].

Ding, Dawei ;

Zhu, Qingdi .

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2018, 92 :1041-1060

[14] Impact of pH, ionic strength and chitosan charge density on chitosan/casein complexation and phase behavior [J].

Ding, Lan ;

Huang, Yan ;

Cai, XiXi ;

Wang, Shaoyun .

CARBOHYDRATE POLYMERS, 2019, 208 :133-141

[15] Encapsulation of grape seed phenolic-rich extract within W/O/W emulsions stabilized with complexed biopolymers: Evaluation of their stability and release [J].

Estevez, Miriam ;

Guell, Carme ;

De Lamo-Castellvi, Silvia ;

Ferrando, Montserrat .

FOOD CHEMISTRY, 2019, 272 :478-487

[16] PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor [J].

Fernandes, Carlos ;

Martins, Claudia ;

Fonseca, Andre ;

Nunes, Rute ;

Matos, Maria Joao ;

Silva, Renata ;

Garrido, Jorge ;

Sarmento, Bruno ;

Remiao, Fernando ;

Otero-Espinar, Francisco J. ;

Uriarte, Eugenio ;

Borges, Fernanda .

ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (46) :39557-39569

[17] Immobilization of Mercury by Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles: Reaction Mechanisms and Effects of Stabilizer and Water Chemistry [J].

Gong, Yanyan ;

Liu, Yuanyuan ;

Xiong, Zhong ;

Zhao, Dongye .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2014, 48 (07) :3986-3994

[18] Synthesis of poly(methyl methacrylate) core/chitosan-mixed-polyethyleneimine shell nanoparticles and their antibacterial property [J].

Inphonlek, Supharat ;

Pimpha, Nuttaporn ;

Sunintaboon, Panya .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2010, 77 (02) :219-226

[19]

Jain A, 2007, J PHARM PHARM SCI, V10, P86

[20] Evaluation of targeted curcumin (CUR) loaded PLGA nanoparticles for in vitro photodynamic therapy on human glioblastoma cell line [J].

Jamali, Zahra ;

Khoobi, Mehdi ;

Hejazi, Sedigheh Marjaneh ;

Eivazi, Neda ;

Abdolahpour, Saeideh ;

Imanparast, Fatemeh ;

Moradi-Sardareh, Hemen ;

Paknejad, Maliheh .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2018, 23 :190-201

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