Metal-organic frameworks for hepatocellular carcinoma therapy and mechanism

被引：6
作者：
Feng, Yingqi [1 ]
Wu, Wei [1 ]
Li, Muzi [1 ]
机构：
[1] Beijing Univ Technol, Dept Environm Chem Engn, Beijing Key Lab Green Catalysis & Separat, Beijing, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷
关键词：
hepatocellular carcinoma; MOFs; photothermal therapy; photodynamic therapy; chemodynamic therapy; MOF NANOSHEETS; DRUG-DELIVERY; NANOPARTICLES; NANOPLATFORM; PORPHYRIN; NMOFS;
D O I：
10.3389/fphar.2022.1025780
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In recent years, metal organic frameworks (MOFs) have attracted increasing attention in cancer therapy, because they can enhance the anticancer efficacy of photodynamic therapy (PDT), photothermal therapy (PTT), photoacoustic imaging, and drug delivery. Owing to stable chemical adjustability, MOFs can be used as carriers to provide excellent loading sites and protection for small-molecule drugs. In addition, MOFs can be used to combine with a variety of therapeutic drugs, including chemotherapeutics drugs, photosensitizers, and radiosensitizers, to efficiently deliver drugs to tumor tissue and achieve desired treatment. There is hardly any review regarding the application of MOFs in hepatocellular carcinoma. In this review, the design, structure, and potential applications of MOFs as nanoparticulate systems in the treatment of hepatocellular carcinoma are presented.Systematic Review Registration: website, identifier registration number
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页数：12
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