A greener approach for the synthesis of pyrido[2,3-d]pyrimidine derivatives in glycerol under microwave heating

被引：5
作者：
Martinho, Luan A. [1 ]
Andrade, Carlos Kleber Z. [1 ]
机构：
[1] Univ Brasilia, Inst Quim, Lab Quim Metodol & Organ Sintet LaQMOS, Brasilia, DF, Brazil
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2022年 / 59卷 / 08期
关键词：
ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; ORGANIC-SYNTHESIS; 3-COMPONENT SYNTHESIS; ANTIFOLATE ACTIVITY; CATALYZED SYNTHESIS; SOLVENT-FREE; CHEMISTRY; ANALOGS; DESIGN;
D O I：
10.1002/jhet.4483
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report the multicomponent synthesis of pyrido[2,3-d]pyrimidine derivatives from 6-aminouracil, aromatic aldehydes, and malononitrile in glycerol as a green solvent under microwave heating. This methodology shows several advantages: catalyst-free synthesis, up to 90% yield, operational simplicity, short reaction times, easy work-up procedure, and a greener approach compared with other methods reported in the literature.
引用
收藏
页码：1417 / 1429
页数：13
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