A greener approach for the synthesis of pyrido[2,3-d]pyrimidine derivatives in glycerol under microwave heating

被引：5

作者：

Martinho, Luan A. ^{[1
]}

Andrade, Carlos Kleber Z. ^{[1
]}

机构：

[1] Univ Brasilia, Inst Quim, Lab Quim Metodol & Organ Sintet LaQMOS, Brasilia, DF, Brazil

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2022年 / 59卷 / 08期

关键词：

ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; ORGANIC-SYNTHESIS; 3-COMPONENT SYNTHESIS; ANTIFOLATE ACTIVITY; CATALYZED SYNTHESIS; SOLVENT-FREE; CHEMISTRY; ANALOGS; DESIGN;

D O I：

10.1002/jhet.4483

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report the multicomponent synthesis of pyrido[2,3-d]pyrimidine derivatives from 6-aminouracil, aromatic aldehydes, and malononitrile in glycerol as a green solvent under microwave heating. This methodology shows several advantages: catalyst-free synthesis, up to 90% yield, operational simplicity, short reaction times, easy work-up procedure, and a greener approach compared with other methods reported in the literature.

引用

收藏

页码：1417 / 1429

页数：13

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