Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma

被引:4
作者
Bague, Silvia [1 ,2 ]
Leon, Xavier [3 ]
Terra, Ximena [4 ]
Lejeune, Marylene [5 ]
Camacho, Mercedes [6 ]
Aviles-Jurado, Francesc-Xavier [7 ]
机构
[1] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Pathol Dept, Barcelona, Spain
[2] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Otorhinolaryngol Dept, Barcelona, Spain
[3] Ctr Invest Biomed Red Bioingn Biomat & Nanomed CI, Madrid, Spain
[4] Univ Rovira & Virgili, Biochem & Biotechnol Dept, MoBioFood Res Grp, Campus Sescellades, Tarragona, Spain
[5] URV, Pathol Dept, Plataforma Estudios Histol Citol & Digitalizac, Hosp Tortosa Verge de la Cinta,Inst Invest Sanita, Tortosa, Spain
[6] Res Inst Hosp St Pau, Genom Complex Dis, Barcelona, Spain
[7] Univ Rovira & Virgili, URV, Hosp Univ Joan XXIII, Otorhinolaryngol Dept,Inst Invest Sanitaria Pere, Tarragona, Spain
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2022年 / 44卷 / 11期
关键词
biomarker; lactate dehydrogenase A; LDHA; head and neck squamous cell carcinoma; Warburg effect; NASOPHARYNGEAL CARCINOMA; SURVIVAL; PREDICTS; CANCER; BIOMARKERS;
D O I
10.1002/hed.27161
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background To analyze the relationship between the transcriptional expression of lactate dehydrogenase A (LDHA) and the disease control in patients with a head and squamous cell carcinoma (HNSCC). Methods We determined the transcriptional expression of LDHA in 110 HNSCC patients treated with surgery. Results Five-year disease-free survival for patients with a high transcriptional expression of LDHA (n = 51) was 39.2% (95% confidence interval [CI]: 25.3%-53.1%), and for patients with a low expression (n = 59), it was 63.6% (95% CI: 51.1%-76.1%) (p = 0.004). According to the results of a multivariate analysis, patients with a high transcriptional expression of LDHA had a 3.4-fold increased risk of tumor recurrence. Patients with a high transcriptional expression of LDHA tended to show a higher intensity of immunohistochemical expression of LDHA at the tumor cells (p = 0.086). Conclusion In HNSCC patients treated with surgery, a high transcriptional expression of LDHA was associated with a significant decrease in disease-free survival.
引用
收藏
页码:2505 / 2512
页数:8
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