Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma

被引：4

作者：

Bague, Silvia ^{[1
,2
]}

Leon, Xavier ^{[3
]}

Terra, Ximena ^{[4
]}

Lejeune, Marylene ^{[5
]}

Camacho, Mercedes ^{[6
]}

Aviles-Jurado, Francesc-Xavier ^{[7
]}

机构：

[1] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Pathol Dept, Barcelona, Spain

[2] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Otorhinolaryngol Dept, Barcelona, Spain

[3] Ctr Invest Biomed Red Bioingn Biomat & Nanomed CI, Madrid, Spain

[4] Univ Rovira & Virgili, Biochem & Biotechnol Dept, MoBioFood Res Grp, Campus Sescellades, Tarragona, Spain

[5] URV, Pathol Dept, Plataforma Estudios Histol Citol & Digitalizac, Hosp Tortosa Verge de la Cinta,Inst Invest Sanita, Tortosa, Spain

[6] Res Inst Hosp St Pau, Genom Complex Dis, Barcelona, Spain

[7] Univ Rovira & Virgili, URV, Hosp Univ Joan XXIII, Otorhinolaryngol Dept,Inst Invest Sanitaria Pere, Tarragona, Spain

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2022年 / 44卷 / 11期

关键词：

biomarker; lactate dehydrogenase A; LDHA; head and neck squamous cell carcinoma; Warburg effect; NASOPHARYNGEAL CARCINOMA; SURVIVAL; PREDICTS; CANCER; BIOMARKERS;

D O I：

10.1002/hed.27161

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background To analyze the relationship between the transcriptional expression of lactate dehydrogenase A (LDHA) and the disease control in patients with a head and squamous cell carcinoma (HNSCC). Methods We determined the transcriptional expression of LDHA in 110 HNSCC patients treated with surgery. Results Five-year disease-free survival for patients with a high transcriptional expression of LDHA (n = 51) was 39.2% (95% confidence interval [CI]: 25.3%-53.1%), and for patients with a low expression (n = 59), it was 63.6% (95% CI: 51.1%-76.1%) (p = 0.004). According to the results of a multivariate analysis, patients with a high transcriptional expression of LDHA had a 3.4-fold increased risk of tumor recurrence. Patients with a high transcriptional expression of LDHA tended to show a higher intensity of immunohistochemical expression of LDHA at the tumor cells (p = 0.086). Conclusion In HNSCC patients treated with surgery, a high transcriptional expression of LDHA was associated with a significant decrease in disease-free survival.

引用

页码：2505 / 2512

页数：8

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