A common origin for immunity and digestion

被引：43
作者：
Broderick, Nichole A. [1 ]
机构：
[1] Yale Univ, Dept Mol Cellular & Devel Biol, New Haven, CT 06520 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷
关键词：
innate immunity; host-microbe interactions; gut microbiome; evolution; metabolism; digestion physiology; DROSOPHILA-MELANOGASTER; INVERTEBRATE LYSOZYMES; METABOLISM; BACTERIA; HOMEOSTASIS; STARVATION; MICROBIOTA; EVOLUTION; SYSTEM; SENSOR;
D O I：
10.3389/fimmu.2015.00072
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Historically, the digestive and immune systems were viewed and studied as separate entities. However, there are remarkable similarities and shared functions in both nutrient acquisition and host defense. Here, I propose a common origin for both systems. This association provides a new prism for viewing the emergence and evolution of host defense mechanisms.
引用
收藏
页数：3
相关论文
共 34 条
  • [1] Bacterial Influences on Animal Origins
    Alegado, Rosanna A.
    King, Nicole
    [J]. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2014, 6 (11):
  • [2] A negative role for MyD88 in the resistance to starvation as revealed in an intestinal infection of Drosophila melanogaster with the Gram-positive bacterium Staphylococcus xylosus
    Ayyaz, Arshad
    Giammarinaro, Philippe
    Liegeois, Samuel
    Lestradet, Matthieu
    Ferrandon, Dominique
    [J]. IMMUNOBIOLOGY, 2013, 218 (04) : 635 - 644
  • [3] Phylogenetic analysis of invertebrate lysozymes and the evolution of lysozyme function
    Bachali, S
    Jager, M
    Hassanin, A
    Schoentgen, F
    Jollès, P
    Fiala-Medioni, A
    Deutsch, JS
    [J]. JOURNAL OF MOLECULAR EVOLUTION, 2002, 54 (05) : 652 - 664
  • [4] FOXO-dependent regulation of innate immune homeostasis
    Becker, Thomas
    Loch, Gerrit
    Beyer, Marc
    Zinke, Ingo
    Aschenbrenner, Anna C.
    Carrera, Pilar
    Inhester, Therese
    Schultze, Joachim L.
    Hoch, Michael
    [J]. NATURE, 2010, 463 (7279) : 369 - 373
  • [5] Cnidarian- Microbe Interactions and the Origin of Innate Immunity in Metazoans
    Bosch, Thomas C. G.
    [J]. ANNUAL REVIEW OF MICROBIOLOGY, VOL 67, 2013, 67 : 499 - 518
  • [6] Immune-like phagocyte activity in the social amoeba
    Chen, Guokai
    Zhuchenko, Olga
    Kuspa, Adam
    [J]. SCIENCE, 2007, 317 (5838) : 678 - 681
  • [7] Transforming Growth Factor β/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression
    Chng, Wen-bin Alfred
    Sleiman, Maroun S. Bou
    Schuepfer, Fanny
    Lemaitre, Bruno
    [J]. CELL REPORTS, 2014, 9 (01): : 336 - 348
  • [8] Transferred interbacterial antagonism genes augment eukaryotic innate immune function
    Chou, Seemay
    Daugherty, Matthew D.
    Peterson, S. Brook
    Biboy, Jacob
    Yang, Youyun
    Jutras, Brandon L.
    Fritz-Laylin, Lillian K.
    Ferrin, Michael A.
    Harding, Brittany N.
    Jacobs-Wagner, Christine
    Yang, X. Frank
    Vollmer, Waldemar
    Malik, Harmit S.
    Mougous, Joseph D.
    [J]. NATURE, 2015, 518 (7537) : 98 - +
  • [9] MEF2 Is an In Vivo Immune-Metabolic Switch
    Clark, Rebecca I.
    Tan, Sharon W. S.
    Pean, Claire B.
    Roostalu, Urmas
    Vivancos, Valerie
    Bronda, Kevin
    Pilatova, Martina
    Fu, Jingqi
    Walker, David W.
    Berdeaux, Rebecca
    Geissmann, Frederic
    Dionne, Marc S.
    [J]. CELL, 2013, 155 (02) : 435 - 447
  • [10] STARVATION OF MARINE FLOUNDER, SQUID AND LABORATORY MICE AND ITS EFFECT ON THE INTESTINAL MICROBIOTA
    CONWAY, PL
    MAKI, J
    MITCHELL, R
    KJELLEBERG, S
    [J]. FEMS MICROBIOLOGY ECOLOGY, 1986, 38 (03) : 187 - 195
1234