Sesquiterpene Farnesol Contributes to Increased Susceptibility to β-Lactams in Strains of Burkholderia pseudomallei

被引：23
|
作者：
Brilhante, R. S. N. [1 ]
Valente, L. G. A. [1 ]
Rocha, M. F. G. [1 ,2 ]
Bandeira, T. J. P. G. [1 ]
Cordeiro, R. A. [1 ]
Lima, R. A. C. [1 ]
Leite, J. J. G. [1 ]
Ribeiro, J. F. [1 ]
Pereira, J. F. [1 ]
Castelo-Branco, D. S. C. M. [1 ]
Monteiro, A. J. [3 ]
Sidrim, J. J. C. [1 ]
机构：
[1] Univ Fed Ceara, Dept Pathol & Legal Med, Specialized Med Mycol Ctr, Postgrad Program Med Microbiol,Sch Med, Fortaleza, Ceara, Brazil
[2] Univ Estadual Ceara, Sch Vet, Postgrad Program Vet Sci, Fortaleza, Ceara, Brazil
[3] Univ Fed Ceara, Dept Stat & Appl Math, Fortaleza, Ceara, Brazil
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期
关键词：
STAPHYLOCOCCUS-AUREUS; BIOFILM FORMATION; IN-VITRO; MELIOIDOSIS; RESISTANCE; GROWTH;
D O I：
10.1128/AAC.05885-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This study aimed to evaluate the in vitro combination of farnesol and beta-lactams against Burkholderia pseudomallei. A total of 12 beta-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 mu M. The combination of this compound with beta-Iactams resulted in statistically significant beta-lactam MIC reduction (P <= 0.05). This study provides new perspectives for the use of farnesol combined with beta-lactam antibiotics against strains of B. pseudomallei.
引用
收藏
页码：2198 / 2200
页数：3
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