Sesquiterpene Farnesol Contributes to Increased Susceptibility to β-Lactams in Strains of Burkholderia pseudomallei

被引：23
|
作者：
Brilhante, R. S. N. [1 ]
Valente, L. G. A. [1 ]
Rocha, M. F. G. [1 ,2 ]
Bandeira, T. J. P. G. [1 ]
Cordeiro, R. A. [1 ]
Lima, R. A. C. [1 ]
Leite, J. J. G. [1 ]
Ribeiro, J. F. [1 ]
Pereira, J. F. [1 ]
Castelo-Branco, D. S. C. M. [1 ]
Monteiro, A. J. [3 ]
Sidrim, J. J. C. [1 ]
机构：
[1] Univ Fed Ceara, Dept Pathol & Legal Med, Specialized Med Mycol Ctr, Postgrad Program Med Microbiol,Sch Med, Fortaleza, Ceara, Brazil
[2] Univ Estadual Ceara, Sch Vet, Postgrad Program Vet Sci, Fortaleza, Ceara, Brazil
[3] Univ Fed Ceara, Dept Stat & Appl Math, Fortaleza, Ceara, Brazil
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期
关键词：
STAPHYLOCOCCUS-AUREUS; BIOFILM FORMATION; IN-VITRO; MELIOIDOSIS; RESISTANCE; GROWTH;
D O I：
10.1128/AAC.05885-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This study aimed to evaluate the in vitro combination of farnesol and beta-lactams against Burkholderia pseudomallei. A total of 12 beta-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 mu M. The combination of this compound with beta-Iactams resulted in statistically significant beta-lactam MIC reduction (P <= 0.05). This study provides new perspectives for the use of farnesol combined with beta-lactam antibiotics against strains of B. pseudomallei.
引用
收藏
页码：2198 / 2200
页数：3
相关论文
共 50 条
  • [31] Recurrent melioidosis:: Possible role of infection with multiple strains of Burkholderia pseudomallei
    Pitt, Tyrone L.
    Trakulsomboon, Suwanna
    Dance, David A. B.
    JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (02) : 680 - 681
  • [32] Protection against heterologous Burkholderia pseudomallei strains by dendritic cell immunization
    Elvin, SJ
    Healey, GD
    Westwood, A
    Knight, SC
    Eyles, JE
    Williamson, ED
    INFECTION AND IMMUNITY, 2006, 74 (03) : 1706 - 1711
  • [33] Antibiotic susceptibility of 50 clinical isolates of Burkholderia pseudomallei from Singapore
    Sivalingam, Suppiah Paramalingam
    Sim, Siew Hoon
    Aw, Lay Tin
    Ooi, Eng Eong
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (05) : 1102 - 1103
  • [34] A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo
    Essex-Lopresti, AE
    Boddey, JA
    Thomas, R
    Smith, MP
    Hartley, MG
    Atkins, T
    Brown, NF
    Tsang, CH
    Peak, IRA
    Hill, J
    Beacham, IR
    Titball, RW
    INFECTION AND IMMUNITY, 2005, 73 (02) : 1260 - 1264
  • [35] Susceptibility of antibiotics for infected Burkholderia pseudomallei patients found in Sapprasithiprasong Hospital
    Panomket, P.
    Jittimanee, J.
    Srivoramas, T.
    Treerotphon, S.
    Wanram, S.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2012, 16 : E429 - E429
  • [36] Comparative in vitro susceptibility of Burkholderia pseudomallei to doripenem, ertapenem, tigecycline and moxifloxacin
    Harris, Patrick
    Engler, Cathy
    Norton, Robert
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 37 (06) : 547 - 549
  • [37] Management of Burkholderia pseudomallei infections: Recent recommendations on antimicrobial susceptibility testing
    Bakthavatchalam, Yamuna Devi
    Mukhopadhyay, Chiranjay
    Veeraraghavan, Balaji
    INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2022, 40 (01) : 176 - 177
  • [38] Characterization of in vitro phenotypes of Burkholderia pseudomallei and Burkholderia mallei strains potentially associated with persistent infection in mice
    Bernhards, R. C.
    Cote, C. K.
    Amemiya, K.
    Waag, D. M.
    Klimko, C. P.
    Worsham, P. L.
    Welkos, S. L.
    ARCHIVES OF MICROBIOLOGY, 2017, 199 (02) : 277 - 301
  • [39] Characterization of in vitro phenotypes of Burkholderia pseudomallei and Burkholderia mallei strains potentially associated with persistent infection in mice
    R. C. Bernhards
    C. K. Cote
    K. Amemiya
    D. M. Waag
    C. P. Klimko
    P. L. Worsham
    S. L. Welkos
    Archives of Microbiology, 2017, 199 : 277 - 301
  • [40] Susceptibility of multiresistant strains of Burkholderia cepacia to honey
    Cooper, RA
    Wigley, P
    Burton, NF
    LETTERS IN APPLIED MICROBIOLOGY, 2000, 31 (01) : 20 - 24
12345