Sesquiterpene Farnesol Contributes to Increased Susceptibility to β-Lactams in Strains of Burkholderia pseudomallei

被引：23

作者：

Brilhante, R. S. N. ^{[1
]}

Valente, L. G. A. ^{[1
]}

Rocha, M. F. G. ^{[1
,2
]}

Bandeira, T. J. P. G. ^{[1
]}

Cordeiro, R. A. ^{[1
]}

Lima, R. A. C. ^{[1
]}

Leite, J. J. G. ^{[1
]}

Ribeiro, J. F. ^{[1
]}

Pereira, J. F. ^{[1
]}

Castelo-Branco, D. S. C. M. ^{[1
]}

Monteiro, A. J. ^{[3
]}

Sidrim, J. J. C. ^{[1
]}

机构：

[1] Univ Fed Ceara, Dept Pathol & Legal Med, Specialized Med Mycol Ctr, Postgrad Program Med Microbiol,Sch Med, Fortaleza, Ceara, Brazil

[2] Univ Estadual Ceara, Sch Vet, Postgrad Program Vet Sci, Fortaleza, Ceara, Brazil

[3] Univ Fed Ceara, Dept Stat & Appl Math, Fortaleza, Ceara, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期

关键词：

STAPHYLOCOCCUS-AUREUS; BIOFILM FORMATION; IN-VITRO; MELIOIDOSIS; RESISTANCE; GROWTH;

D O I：

10.1128/AAC.05885-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study aimed to evaluate the in vitro combination of farnesol and beta-lactams against Burkholderia pseudomallei. A total of 12 beta-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 mu M. The combination of this compound with beta-Iactams resulted in statistically significant beta-lactam MIC reduction (P <= 0.05). This study provides new perspectives for the use of farnesol combined with beta-lactam antibiotics against strains of B. pseudomallei.

引用

页码：2198 / 2200

页数：3

共 50 条

[21] Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents
Thibault, FM
Hernandez, E
Vidal, DR
Girardet, M
Cavallo, JD
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 54 (06) : 1134 - 1138
[22] A comparison of antibiotic susceptibility testing methods for cotrimoxazole with Burkholderia pseudomallei
Piliouras, P
Ulett, GC
Ashhurst-Smith, C
Hirst, RG
Norton, RE
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2002, 19 (05) : 427 - 429
[23] Reduced susceptibility of Malaysian clinical isolates of Burkholderia pseudomallei to ciprofloxacin
Liew, F. Y.
Tay, S. T.
Puthucheary, S. D.
TROPICAL BIOMEDICINE, 2011, 28 (03) : 646 - 650
[24] Antimicrobial susceptibility pattern of clinical isolates of Burkholderia pseudomallei in Bangladesh
Dutta S.
Haq S.
Hasan M.R.
Haq J.A.
BMC Research Notes, 10 (1)
[25] Burkholderia pseudomallei: In vitro susceptibility to some new and old antimicrobials
Karunakaran, Rina
Puthucheary, Savithri D.
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2007, 39 (10) : 858 - 861
[26] Susceptibility of Clinical Isolates of Burkholderia pseudomallei to a Lipid A Biosynthesis Inhibitor
Sengyee, Sineenart
Saiprom, Natnaree
Paksanont, Suporn
Limmathurotsakul, Direk
Wuthiekanun, Vanaporn
Chantratita, Narisara
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2017, 97 (01): : 62 - 67
[27] Comparative in vitro susceptibility of Burkholderia pseudomallei to cefpirome, ceftazidime and cefepime
SeymourMurray, J
Norton, R
AshhurstSmith, C
PATHOLOGY, 1997, 29 (03) : 329 - 330
[28] In Vitro Susceptibility of Ceftolozane-Tazobactam against Burkholderia pseudomallei
Chan, Elaine
Martelli, Paolo
Hui, Suk-Wai
Teng, Jade L. L.
Lau, Susanna K. P.
Woo, Patrick C. Y.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (05)
[29] Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to P-lactams in methicillin-resistant Staphylococcus aureus
Kuroda, Makoto
Nagasaki, Sanae
Ohta, Toshiko
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (03) : 425 - 432
[30] Correlation between biofilm production, antibiotic susceptibility and exopolysaccharide composition in Burkholderia pseudomallei bpsI, ppk, and rpoS mutant strains
Mongkolrob, Rungrawee
Taweechaisupapong, Suwimol
Tungpradabkul, Sumalee
MICROBIOLOGY AND IMMUNOLOGY, 2015, 59 (11) : 653 - 663

← 1 2 3 4 5 →