Sesquiterpene Farnesol Contributes to Increased Susceptibility to β-Lactams in Strains of Burkholderia pseudomallei

被引：23

作者：

Brilhante, R. S. N. ^{[1
]}

Valente, L. G. A. ^{[1
]}

Rocha, M. F. G. ^{[1
,2
]}

Bandeira, T. J. P. G. ^{[1
]}

Cordeiro, R. A. ^{[1
]}

Lima, R. A. C. ^{[1
]}

Leite, J. J. G. ^{[1
]}

Ribeiro, J. F. ^{[1
]}

Pereira, J. F. ^{[1
]}

Castelo-Branco, D. S. C. M. ^{[1
]}

Monteiro, A. J. ^{[3
]}

Sidrim, J. J. C. ^{[1
]}

机构：

[1] Univ Fed Ceara, Dept Pathol & Legal Med, Specialized Med Mycol Ctr, Postgrad Program Med Microbiol,Sch Med, Fortaleza, Ceara, Brazil

[2] Univ Estadual Ceara, Sch Vet, Postgrad Program Vet Sci, Fortaleza, Ceara, Brazil

[3] Univ Fed Ceara, Dept Stat & Appl Math, Fortaleza, Ceara, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期

关键词：

STAPHYLOCOCCUS-AUREUS; BIOFILM FORMATION; IN-VITRO; MELIOIDOSIS; RESISTANCE; GROWTH;

D O I：

10.1128/AAC.05885-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study aimed to evaluate the in vitro combination of farnesol and beta-lactams against Burkholderia pseudomallei. A total of 12 beta-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 mu M. The combination of this compound with beta-Iactams resulted in statistically significant beta-lactam MIC reduction (P <= 0.05). This study provides new perspectives for the use of farnesol combined with beta-lactam antibiotics against strains of B. pseudomallei.

引用

页码：2198 / 2200

页数：3

共 18 条

[1] Sensitization of Staphylococcus aureus and Escherichi coli to antibiotics by the sesquiterpenoid nerolidol, farnesol, bisabolol, and apritone [J].