Serum apelin-13 levels and total oxidant/antioxidant status of patients with Alzheimer's disease

ObjectiveWe aimed to evaluate apelin-13 levels, total oxidant/antioxidant status in Alzheimer's disease (AD) and to investigate the relationship between these parameters.MethodsPatients newly diagnosed with AD were enrolled in the study. The control group consisted of age- and gender-matched healthy individuals. Serum levels of apelin-13, total antioxidant status (TAS), and total oxidant status (TOS) were measured. Oxidative stress index was calculated (TOS/TAS) for each participant.ResultsWe reported that serum apelin-13 and TAS values were significantly lower in the AD group compared with controls, and they found a fair but insignificant relationship between Apelin-13 and TAS values.ConclusionAccording to our results, we suggested that insufficient apelin-13 and TAS levels may contribute to the pathogenesis of AD. The purpose of this study was to evaluate apelin-13 levels, total antioxidant status (TAS), and total oxidant status (TOS) in Alzheimer's disease (AD) and investigate the relationship among these parameters. Patients newly diagnosed with AD were enrolled in the study. The control group consisted of age- and gender-matched healthy individuals. Serum levels of apelin-13, TAS, and TOS were measured. Oxidative stress index was calculated (TOS/TAS) for each participant. Apelin-13 and TAS values were significantly lower in the AD group compared to controls. There was a fair but insignificant correlation between apelin-13 and TAS values. Insufficient levels of apelin-13 and TAS may contribute to the pathogenesis of AD.image