Does functional depletion of stem cells drive aging?

被引：51
作者：
Schlessinger, D
Van Zant, G
机构：
[1] NIA, Genet Lab, Gerontol Res Ctr, NIH, Baltimore, MD 21218 USA
[2] Univ Kentucky, Med Ctr, Markey Canc Ctr, Div Hematol Oncol, Lexington, KY 40536 USA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2001年 / 122卷 / 14期
关键词：
immortal cells; ovarian follicles; hematopoiesis; lifespan;
D O I：
10.1016/S0047-6374(01)00299-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The regenerative power of stem cells has raised issues about their relation to aging. We focus on the question of whether a decline in the function of stem cells may itself be a significant feature of aging. The question is implicitly two-fold: does functional depletion of stem cells affect the accumulation of aging-related deficits, and -- whether or not depletion is significant -- can activation of stem cells alleviate deficits? Two types of system are considered: 1) the exhaustible pool of ovarian follicles. The depletion of follicles leads to the aging-related phenomenon of menopause: and 2) the reserve of hematopoietic stem cells. Substantial numbers are sustained throughout life, but in mouse models. endogenous replicative activity has been shown to decline sharply with age. We discuss the possible implications of these observations for the rate of aging and the prospects for intervention. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：1537 / 1553
页数：17
相关论文
共 74 条
[41]   New paradigms for research on aging and late-life illness [J].
Miller, RA .
MECHANISMS OF AGEING AND DEVELOPMENT, 2001, 122 (02) :130-132
[42]   Intrinsic immunological tolerance in allophenic mice (Reprinted from Science, vol 158, pg 1484-1487, 1967) [J].
Mintz, Beatrice ;
Silvers, Willys K. .
JOURNAL OF IMMUNOLOGY, 2007, 178 (07) :4007-4010
[43]   GENE CONTROL OF HEMATOPOIESIS .I. ERYTHROCYTE MOSAICISM AND PERMANENT IMMUNOLOGICAL TOLERANCE IN ALLOPHENIC MICE [J].
MINTZ, B ;
PALM, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1969, 129 (05) :1013-&
[44]   Adrenalectomy increases neurogenesis but not PSA-NCAM expression in aged dentate gyrus [J].
Montaron, MF ;
Petry, KG ;
Rodriguez, JJ ;
Marinelli, M ;
Aurousseau, C ;
Rougon, G ;
Le Moal, M ;
Abrous, DN .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (04) :1479-1485
[45]   Oocyte apoptosis: Like sand through an hourglass [J].
Morita, Y ;
Tilly, JL .
DEVELOPMENTAL BIOLOGY, 1999, 213 (01) :1-17
[46]   Targeted expression of Bcl-2 in mouse oocytes inhibits ovarian follicle atresia and prevents spontaneous and chemotherapy-induced oocyte apoptosis in vitro [J].
Morita, Y ;
Perez, GI ;
Maravei, DV ;
Tilly, KI ;
Tilly, JL .
MOLECULAR ENDOCRINOLOGY, 1999, 13 (06) :841-850
[47]   The aging of hematopoietic stem cells [J].
Morrison, SJ ;
Wandycz, AM ;
Akashi, K ;
Globerson, A ;
Weissman, IL .
NATURE MEDICINE, 1996, 2 (09) :1011-1016
[48]   Diversification of haematopoietic stem cells to specific lineages [J].
Orkin, SH .
NATURE REVIEWS GENETICS, 2000, 1 (01) :57-64
[49]   Exceptional familial clustering for extreme longevity in humans [J].
Perls, T ;
Shea-Drinkwater, M ;
Bowen-Flynn, J ;
Ridge, SB ;
Kang, S ;
Joyce, E ;
Daly, M ;
Brewster, SJ ;
Kunkel, L ;
Puca, AA .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2000, 48 (11) :1483-1485
[50]   Siblings of centenarians live longer [J].
Perls, TT ;
Bubrick, E ;
Wager, CG ;
Vijg, J ;
Kruglyak, L .
LANCET, 1998, 351 (9115) :1560-1560
12345678