An unusual formation of diarylmethane scaffolds from 4-(halomethyl)cyclohex-2-enone derivatives

被引：6

作者：

Babu, Kaki Raveendra ^{[1
]}

Khan, Faiz Ahmed ^{[1
]}

机构：

[1] Indian Inst Technol Hyderabad, Dept Chem, Yeddumailaram 502205, India

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 27期

关键词：

Diarylmethane; 1,6-Conjugate addition; alpha-Diketone; Grob-fragmentation; C-C bond cleavage; REVERSE-TRANSCRIPTASE INHIBITORS; BIOLOGICAL EVALUATION; ENHANCED POTENCIES; COSALANE ANALOGS; ALPHA-DIKETONES; AGENTS; EFFICIENT; DESIGN; SERIES; ALKENYLDIARYLMETHANES;

D O I：

10.1016/j.tetlet.2015.04.128

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient base promoted one-pot dimerization of halo cyclohexene derivatives leading to a de novo synthesis of biologically important diarylmethane and diarylmethanone derivatives is reported. A plausible mechanism for the unexpected formation of the title compounds involves dehydrohalogenation, 1,6-conjugate addition, subsequent aromatization through C-C bond cleavage and dehydrohalogenation. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4067 / 4070

页数：4

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