Differential prognostic relevance of patho-anatomical factors among different tumor-biological subsets of breast cancer: Results from the adjuvant SUCCESS A study

被引：9

作者：

Deniz, Miriam ^{[1
]}

DeGregorio, Amelie ^{[1
]}

DeGregorio, Nikolaus ^{[1
]}

Bekes, Inga ^{[1
]}

Widschwendter, Peter ^{[1
]}

Schochter, Fabienne ^{[1
]}

Ernst, Kristina ^{[1
]}

Scholz, Christoph ^{[1
]}

Bauer, Emanuel C. A. ^{[1
]}

Aivazova-Fuchs, Viktoria ^{[2
]}

Weissenbacher, Tobias ^{[3
]}

Kost, Bernd ^{[3
]}

Jueckstock, Julia ^{[3
]}

Andergassen, Ullrich ^{[3
]}

Steidl, Julia ^{[3
]}

Trapp, Elisabeth ^{[3
]}

Fasching, Peter A. ^{[4
]}

Haeberle, Lothar ^{[4
]}

Beckmann, Matthias W. ^{[4
]}

Schneeweiss, Andreas ^{[5
]}

Schrader, Iris ^{[6
]}

Janni, Wolfgang ^{[1
]}

Rack, Brigitte ^{[1
]}

Friedl, Thomas W. P. ^{[1
]}

机构：

[1] Univ Ulm, Dept Gynecol & Obstet, Prittwitzstr 43, D-89075 Ulm, Germany

[2] Klin Bad Trissl GmbH, Bad Trissl Str 73, D-83080 Oberaudorf, Germany

[3] Univ Munich, Dept Gynecol & Obstet, Campus Innenstadt Ludwig Maximilian,Maistr 11, D-80539 Munich, Germany

[4] Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, Schlosspl 4, D-91054 Erlangen, Germany

[5] Heidelberg Univ, Dept Gynecol & Obstet, Grabengasse 1, D-69117 Heidelberg, Germany

[6] Gynecol Oncol Off, Pelikanpl 23, D-30177 Hannover, Germany

来源：

BREAST | 2019年 / 44卷

关键词：

High-risk breast cancer; Prognostic factors; Molecular subtype; Tumor size; Nodal stage; Interaction effects; HISTOLOGICAL GRADE; SURVIVAL; STAGE; WOMEN; RECURRENCE; CONSENSUS; SUBTYPES; SIZE;

D O I：

10.1016/j.breast.2018.12.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: In breast cancer, large tumor size, positive nodal stage and a triple-negative tumor subtype are associated with reduced survival, but the interactions between these prognostic factors are not well understood. Material and methods: Here we re-evaluated the impact of tumor size, nodal stage and tumor subtype on disease-free survival (DFS), overall survival (OS), distant disease-free survival (DDFS) and breast cancer specific survival (BCSS) in a retrospective analysis using data from the adjuvant SUCCESS A trial. Subgroup analyses were conducted to assess whether the effect of tumor size and nodal stage on survival depended on tumor subtype. Results: Increasing tumor size, higher nodal stage and triple negative breast cancer (TNBC) were associated with unfavorable prognosis (all p <0.001). There was no significant interaction between tumor subtype and tumor size (p > 0.5 for all four survival endpoints), but we found significant interactions between tumor subtype and nodal stage (p <0.05 for all four survival endpoints), with no differences in survival among tumor subtypes for patients with pN0 tumors (all p> 0.05) and pronounced differences in survival among tumor subtypes for patients with positive nodal stage (all p <0.001). Conclusions: This analysis confirms tumor size, nodal stage and tumor subtype as independent prognostic factors in high-risk early breast cancer. Nodal-positive patients with TNBC had a considerably worse outcome compared to nodal-positive patients with another tumor subtype. This underlines the importance for early detection particularly for patients with TNBC. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：81 / 89

页数：9

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