Striatal dopamine level increases in the urinary storage phase in cats:: An in vivo microdialysis study

被引:32
作者
Yamamoto, T
Sakakibara, R
Hashimoto, K
Nakazawa, K
Uchiyama, T
Liu, Z
Ito, T
Hattori, T
机构
[1] Chiba Univ, Dept Neurol, Chuo Ku, Chiba 2608670, Japan
[2] Chiba Univ, Dept Psychiat, Chiba 2608670, Japan
[3] Chiba Univ, Dept Integrat Neurophysiol, Chiba 2608670, Japan
关键词
nigrostriatal dopaminergic neuron; microdialysis; basal ganglia; micturition reflex; Parkinson's disease;
D O I
10.1016/j.neuroscience.2005.06.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Parkinson's disease is a common neurodegenerative disease that shows not only movement disorder, but also profound urinary dysfunction. Bladder hyperactivity is the major urodynamic abnormality. Therefore, the basal ganglia have been thought to modulate the micturition reflex. In six male adult cats under ketamine anesthesia, in which spontaneous isovolumetric micturition reflexes had been generated, we measured levels of striatal dopamine, in micturition and storage phases, using in vivo microdialysis. The striatal dopamine level significantly increased in the storage phase as compared with that in the micturition phase. It is suggested that striatal dopamine may inhibit the micturition reflex via the dopamine D1 receptor-GABAergic direct striatal output pathway, and that disruption of this pathway may be what leads to bladder hyperactivity in patients with Parkinson's disease. (c) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:299 / 303
页数:5
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