Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera

We introduce a new multi aperture system capable of capturing six identical images of the human fundus at six different spectral bands. The system is based on a lenslet array architecture and is well suited for spectroscopy application. The multi-aperture system was interfaced with a fundus camera to acquire spectroscopic sensitive images of the retina vessel and ultimately to calculate oxygen saturation in the retina in vivo. In vitro testing showed that the system is able to accurately reconstruct curves of partially oxygenated hemoglobin. In vivo testing on healthy volunteers was conducted and yielded results of oxygen saturation similar to the one reported in the literature, with arterial SO2 similar to 0.95 and venous SO2 similar to 0.5. (c) 2008 Optical Society of America.