Multifunctional Virus Manipulation with Large-Scale Arrays of All-Dielectric Resonant Nanocavities

被引:43
作者
Shi, Yuzhi [1 ]
Wu, Yongfeng [2 ]
Chin, Lip Ket [3 ]
Li, Zhenyu [3 ]
Liu, Jingquan [1 ]
Chen, Mu Ku [4 ]
Wang, Shubo [5 ]
Zhang, Yi [6 ]
Liu, Patricia Yang [3 ]
Zhou, Xiaohong [7 ]
Cai, Hong [8 ]
Jin, Wanzhen [9 ]
Yu, Yefeng [9 ]
Yu, Ruozhen [10 ]
Huang, Wei [11 ]
Yap, Peng Huat [12 ]
Xiao, Limin [13 ]
Ser, Wee [3 ]
Nguyen, Thi Thanh Binh [3 ]
Lin, Yu-Tsung [14 ]
Wu, Pin Chieh [14 ]
Liao, Jiayan [15 ]
Wang, Fan [15 ]
Chan, C. T. [16 ]
Kivshar, Yuri [4 ,17 ]
Tsai, Din Ping [4 ]
Liu, Ai Qun [3 ]
机构
[1] Shanghai Jiao Tong Univ, Natl Key Lab Sci & Technol Micro Nano Fabricat, Shanghai 200240, Peoples R China
[2] Nanjing Univ Informat Sci & Technol, Sch Phys & Optoelect Engn, Nanjing 210044, Peoples R China
[3] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore
[4] City Univ Hong Kong, Dept Elect Engn, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China
[5] City Univ Hong Kong, Dept Phys, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China
[6] Nanyang Technol Univ, Sch Mech & Aerosp Engn, Singapore 639798, Singapore
[7] Tsinghua Univ, Sch Environm, State Key Joint Lab ESPC, Beijing 100084, Peoples R China
[8] ASTAR, Inst Microelect, Singapore 138634, Singapore
[9] Nanjing Univ Sci & Technol, Sch Elect & Opt Engn, Nanjing 210094, Jiangsu, Peoples R China
[10] Chinese Res Inst Environm Sci, Beijing 100012, Peoples R China
[11] Chinese Acad Sci, Suzhou Inst Nanotech & NanoBion SINANO, Key Lab Multifunct Nanomat & Smart Syst, Suzhou 215123, Peoples R China
[12] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 308232, Singapore
[13] Fudan Univ, Sch Informat Sci & Technol, Shanghai Engn Res Ctr Ultraprecis Opt Mfg,Adv Fib, Key Lab Informat Sci Electromagnet Waves MoE,Key, Shanghai 200433, Peoples R China
[14] Natl Cheng Kung Univ, Dept Photon, Tainan 70101, Taiwan
[15] Univ Technol Sydney, Fac Sci, Inst Biomed Mat & Devices IBMD, Sydney, NSW 2007, Australia
[16] Hong Kong Univ Sci & Technol, Dept Phys, Hong Kong, Peoples R China
[17] Australian Natl Univ, Res Sch Phys, Nonlinear Phys Ctr, Canberra, ACT 2601, Australia
基金
新加坡国家研究基金会; 澳大利亚研究理事会;
关键词
all-dielectric nanocavities; multifunctional virus manipulation chip; optical tweezers; optofluidics; versatile optical manipulations; BOUND-STATES; OPTICAL MANIPULATION; SINGLE VIRUSES; LONG-RANGE; LIGHT; NANOPARTICLES; BINDING;
D O I
10.1002/lpor.202100197
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Spatial manipulation of a precise number of viruses for host cell infection is essential for the extensive studies of virus pathogenesis and evolution. Albeit optical tweezers have been advanced to the atomic level via optical cooling, it is still challenging to efficiently trap and manipulate arbitrary number of viruses in an aqueous environment, being restricted by insufficient strength of optical forces and a lack of multifunctional spatial manipulation techniques. Here, by employing the virus hopping and flexibility of moving the laser position, multifunctional virus manipulation with a large trapping area is demonstrated, enabling single or massive (a large quantity of) virus transporting, positioning, patterning, sorting, and concentrating. The enhanced optical forces are produced by the confinement of light in engineered arrays of nanocavities by fine tuning of the interference resonances, and this approach allows trapping and moving viruses down to 40 nm in size. The work paves the way to efficient and precise manipulation of either single or massive groups of viruses, opening a wide range of novel opportunities for virus pathogenesis and inhibitor development at the single-virus level.
引用
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页数:10
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