Green synthesis of silver nanoparticles using Caesalpinia bonducella leaf extract: characterization and evaluation of in vitro anti-inflammatory and anti-cancer activities

Plant intervened synthesis of nanoparticles has attracted an ample amount of attention because this method is facile, cost-efficient, and eco-friendly. The present study aims to synthesize AgNPs using Caesalpinia bonducella leaf extract by employing a green chemistry approach and was characterized. UV-visible spectroscopy revealed characteristic absorption maxima at 434 nm. FT-IR studies affirmed presence of phytoconstituents that supports role of metabolites as a reducing and capping agent. TEM and FESEM analysis reveal nanoparticles are spherical in shape and EDS confirmed presence of elemental signature of silver at 3 KeV. XRD disclosed crystalline nature of AgNPs with crystalline size of 15.17 nm and Zeta potential at -30 mV indicates good stability. AgNPs showed good anti-inflammatory potential. Anti-cancer activity of AgNPs revealed potential efficacy against MCF-7 cell lines with 24 h IC50 value of 25 mu g/mL. Conferring results, present reports that the biological synthesis method was found highly beneficial in fabrication nanoparticles in medicinal applications.