Biology of immune responses to vaccines in elderly persons

被引:292
作者
Weinberger, Birgit [1 ]
Herndler-Brandstetter, Dietmar [1 ]
Schwanninger, Angelika [1 ]
Weiskopf, Daniela [1 ]
Grubeck-Loebenstein, Beatrix [1 ]
机构
[1] Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria
基金
奥地利科学基金会;
关键词
D O I
10.1086/529197
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
With increasing age, the human immune system undergoes characteristic changes, termed immunosenescence, which lead to increased incidence and severity of infectious diseases and to insufficient protection following vaccination. Functional defects and altered frequencies of innate and adaptive immune cells impair local responses at the site of vaccine injection, hamper the generation of primary responses to neoantigens, prevent the effective induction of memory lymphocytes, and decrease the effect of booster vaccination. As a result, antibody responses of elderly vaccinees are weaker and decline faster, and long-term protective effects of vaccination cannot be taken for granted in elderly persons. Improved vaccination strategies, new adjuvants, and new vaccines that specifically target the aged immune system will help to overcome the limitations of immunosenescence and ensure a better protection of the vulnerable elderly population.
引用
收藏
页码:1078 / 1084
页数:7
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