共 48 条
Biology of immune responses to vaccines in elderly persons
被引:292
作者:

Weinberger, Birgit
论文数: 0 引用数: 0
h-index: 0
机构:
Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria

Herndler-Brandstetter, Dietmar
论文数: 0 引用数: 0
h-index: 0
机构:
Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria

Schwanninger, Angelika
论文数: 0 引用数: 0
h-index: 0
机构:
Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria

Weiskopf, Daniela
论文数: 0 引用数: 0
h-index: 0
机构:
Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria

Grubeck-Loebenstein, Beatrix
论文数: 0 引用数: 0
h-index: 0
机构:
Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria
机构:
[1] Austrian Acad Sci, Inst Biomed Aging Res, Div Immunol, A-6020 Innsbruck, Austria
基金:
奥地利科学基金会;
关键词:
D O I:
10.1086/529197
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
With increasing age, the human immune system undergoes characteristic changes, termed immunosenescence, which lead to increased incidence and severity of infectious diseases and to insufficient protection following vaccination. Functional defects and altered frequencies of innate and adaptive immune cells impair local responses at the site of vaccine injection, hamper the generation of primary responses to neoantigens, prevent the effective induction of memory lymphocytes, and decrease the effect of booster vaccination. As a result, antibody responses of elderly vaccinees are weaker and decline faster, and long-term protective effects of vaccination cannot be taken for granted in elderly persons. Improved vaccination strategies, new adjuvants, and new vaccines that specifically target the aged immune system will help to overcome the limitations of immunosenescence and ensure a better protection of the vulnerable elderly population.
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页码:1078 / 1084
页数:7
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