Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex

被引：251

作者：

Mukherjee, Arup ^{[1
]}

Srimani, Dipankar ^{[1
]}

Chakraborty, Subrata ^{[1
]}

Ben-David, Yehoshoa ^{[1
]}

Milstein, David ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 28期

基金：

以色列科学基金会; 欧洲研究理事会;

关键词：

ENVIRONMENTALLY BENIGN; ELECTRONIC-STRUCTURE; REDUCTIVE AMINATION; SECONDARY ALCOHOLS; IRON CATALYSTS; KETONES; MILD; EFFICIENT; AMMONIA; LIGAND;

D O I：

10.1021/jacs.5b04879

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, With a single exception. Here We report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.

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收藏

页码：8888 / 8891

页数：4

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