Toward the clinical use of circulating biomarkers predictive of bone union

被引：6

作者：

Chaverri, Daniel ^{[1
]}

Vives, Joaquim ^{[2
,3
,4
]}

机构：

[1] Hosp ASEPEYO St Cugat, Avinguda Alcalde Barnils 54-60, Barcelona 08174, Spain

[2] Banc Sang & Teixits, Serv Terapia Cellular, Edifici Dr Frederic Duran i Jorda, Barcelona 08005, Spain

[3] Univ Autonoma Barcelona, Dept Med, Passeig Vall dHebron 129-139, Barcelona 08035, Spain

[4] Univ Autonoma Barcelona, Vall dHebron Res Inst VHIR, Musculoskeletal Tissue Engn Grp, Passeig Vall dHebron 129-139, Barcelona 08035, Spain

来源：

BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 12期

关键词：

biomarker; nonunion; osteogenesis; pseudoarthrosis; regenerative medicine; TGF-beta; 1; RESISTANT ACID-PHOSPHATASE; FIBROBLAST-GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; IN-VITRO; FACTOR-BETA; FRACTURE; METABOLISM; TGF-BETA-1; DIFFERENTIATION; MARKER;

D O I：

10.2217/bmm-2017-0180

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Current methods for diagnosis of bone healing after treatment of trauma injuries rely on clinical findings and the use of imaging methodologies that provide conclusive results but only at mid/long-term post-intervention. In this Perspective we present and discuss incipient evidence on biomarkers that may serve for monitoring the progression of bone healing as well as predicting eventual nonunion outcomes.

引用

页码：1125 / 1133

页数：9

共 48 条

[1]

Ajai AS Singh., 2013, INT RES J BIOL SCI, V2, P40

[2]

ASSOIAN RK, 1983, J BIOL CHEM, V258, P7155

[3] Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase [J].

Ek-Rylander, Barbro ;

Andersson, Goran .

EXPERIMENTAL CELL RESEARCH, 2010, 316 (03) :443-451

[4]

EKRYLANDER B, 1994, J BIOL CHEM, V269, P14853

[5] Effects of proteolysis and reduction on phosphatase and ROS-generating activity of human tartrate-resistant acid phosphatase [J].

Fagerlund, KM ;

Ylipahkala, H ;

Tiitinen, SL ;

Janckila, AJ ;

Hamilton, S ;

Mäentausta, O ;

Väänänen, HK ;

Halleen, JM .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2006, 449 (1-2) :1-7

[6] Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components [J].

Fekete, Natalie ;

Gadelorge, Melanie ;

Fuerst, Daniel ;

Maurer, Caroline ;

Dausend, Julia ;

Fleury-Cappellesso, Sandrine ;

Mailaender, Volker ;

Lotfi, Ramin ;

Ignatius, Anita ;

Sensebe, Luc ;

Bourin, Philippe ;

Schrezenmeier, Hubert ;

Rojewski, Markus Thomas .

CYTOTHERAPY, 2012, 14 (05) :540-554

[7] Mutational analysis of the interaction between active site residues and the loop region in mammalian purple acid phosphatases [J].

Funhoff, EG ;

Ljusberg, J ;

Wang, YL ;

Andersson, G ;

Averill, BA .

BIOCHEMISTRY, 2001, 40 (38) :11614-11622

[8] New developments in biological markers of bone metabolism in osteoporosis [J].

Garnero, Patrick .

BONE, 2014, 66 :46-55

[9] Fracture heating: The diamond concept [J].

Giannoudis, Peter V. ;

Einhorn, Thomas A. ;

Marsh, David .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2007, 38 :S3-S6

[10] FGF23 Is a Putative Marker for Bone Healing and Regeneration [J].

Goebel, Sascha ;

Lienau, Jasmin ;

Rammoser, Ulrich ;

Seefried, Lothar ;

Wintgens, Karl Florian ;

Seufert, Jochen ;

Duda, Georg ;

Jakob, Franz ;

Ebert, Regina .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2009, 27 (09) :1141-1146

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