Hydroalcoholic extract of Zizyphus jujuba ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats

被引：62

作者：

Pahuja, Monika ^{[1
]}

Mehla, Jogender ^{[1
]}

Reeta, K. H. ^{[1
]}

Joshi, Sujata ^{[1
]}

Gupta, Yogendra Kumar ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India

来源：

EPILEPSY & BEHAVIOR | 2011年 / 21卷 / 04期

关键词：

Zizyphus jujuba; Experimental seizure models; Cognitive impairment; Oxidative stress; Cholinesterase activity; PILOCARPINE-INDUCED SEIZURES; CHOLINE-ACETYLTRANSFERASE; ACETYLCHOLINESTERASE ACTIVITIES; SPINOSI-SEMEN; PHENYTOIN; MELATONIN; MEMORY; DAMAGE; HIPPOCAMPUS; MODULATION;

D O I：

10.1016/j.yebeh.2011.05.013

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The anticonvulsant effect of the hydroalcoholic extract of Zizyphus jujuba (HEZJ) fruit (100, 250, 500, and 1000 mg/kg, orally) was evaluated in experimental seizure models in rats. The effect of HEZJ on seizure-induced cognitive impairment, oxidative stress, and cholinesterase activity was also investigated. HEZJ (1000 mg/kg) exhibited maximum protection (100%) against generalized tonic-clonic seizures in the pentylenetetrazole (PTZ) seizure model and and 66.7% protection against tonic hindlimb extension in the maximal electroshock (MES) seizure model. Significant impairment in cognitive functions was observed in both PTZ- and MES-challenged rats. Pretreatment with HEZJ resulted in significant improvement in learning and memory. HEZJ also reversed the oxidative stress induced by both PTZ and MES. The significant decrease in cholinesterase activity observed in the PTZ and MES models was significantly reversed by pretreatment with HEZJ. Thus, the present study demonstrates the anticonvulsant effect of HEZJ as well as amelioration of cognitive impairment induced by seizures in rats. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：356 / 363

页数：8

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