Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides

被引：10

作者：

Amatya, Reeju ^{[1
,2
]}

Park, Taehoon ^{[1
,2
]}

Hwang, Seungmi ^{[3
,4
]}

Yang, JaeWook ^{[5
,6
]}

Lee, Yoonjin ^{[6
]}

Cheong, Heesun ^{[7
]}

Moon, Cheol ^{[8
]}

Kwak, Hyun Duck ^{[5
]}

Min, Kyoung Ah ^{[3
,4
]}

Shin, Meong Cheol ^{[1
,2
]}

机构：

[1] Gyeongsang Natl Univ, Coll Pharm, 501 Jinju Daero, Jinju 52828, Gyeongnam, South Korea

[2] Gyeongsang Natl Univ, Pharmaceut Sci Res Inst, 501 Jinju Daero, Jinju 52828, Gyeongnam, South Korea

[3] Inje Univ, Coll Pharm, 197 Injero, Gimhae 50834, Gyeongnam, South Korea

[4] Inje Univ, Inje Inst Pharmaceut Sci & Res, 197 Injero, Gimhae 50834, Gyeongnam, South Korea

[5] Inje Univ, Coll Med, Dept Ophthalmol, Busan Paik Hosp, 75 Bokjiro, Busan 47392, South Korea

[6] Inje Univ, Busan Paik Hosp, T2B Infrastruct Ctr Ocular Dis, 81 Jinsaro 83 Beon Gil, Busan 47397, South Korea

[7] Natl Canc Ctr, Div Canc Biol, 323 Ilsan Ro, Goyang 10408, Gyeonggi Do, South Korea

[8] Sunchon Natl Univ, Coll Pharm, 255 Jungang Ro, Sunchon 57922, Jeonnam, South Korea

来源：

TOXINS | 2020年 / 12卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

toxin; diabetes; anti-diabetic peptide; drug delivery; plasma half-life; cell-penetrating peptide; AMINO-ACID SUBSTITUTION; ALBUMIN FUSION PROTEIN; HOST-DEFENSE PEPTIDES; NEONATAL FC-RECEPTOR; BETA-CELL FUNCTION; ANTIMICROBIAL PEPTIDES; HALF-LIFE; SERUM-ALBUMIN; SKIN SECRETIONS; INSULINOTROPIC ACTIONS;

D O I：

10.3390/toxins12050313

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Toxin peptides derived from the skin secretions of amphibians possess unique hypoglycemic activities. Many of these peptides share cationic and amphipathic structural similarities and appear to possess cell-penetrating abilities. The mechanism of their insulinotropic action is yet not elucidated, but they have shown great potential in regulating the blood glucose levels in animal models. Therefore, they have emerged as potential drug candidates as therapeutics for type 2 diabetes. Despite their anti-diabetic activity, there remain pharmaceutical challenges to be addressed for their clinical applications. Here, we present an overview of recent studies related to the toxin-derived anti-diabetic peptides derived from the skin secretions of amphibians. In the latter part, we introduce the bottleneck challenges for their delivery in vivo and general drug delivery strategies that may be applicable to extend their blood circulation time. We focus our research on the strategies that have been successfully applied to improve the plasma half-life of exendin-4, a clinically available toxin-derived anti-diabetic peptide drug.

引用

页数：18

共 100 条

[1] Brevinin-2-related Peptide and its [D4K] Analogue Stimulate Insulin Release In Vitro and Improve Glucose Tolerance in Mice Fed a High Fat Diet [J].