Studies on isocyanides.: A facile synthesis of 4,5-dihydro-1,4-benzothiazepin-3(2H)-ones via post-condensation modifications of the Ugi reaction

被引:23
作者
Neo, AG
Marcos, CF
Marcaccini, S
Pepino, R
机构
[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50019 Sesto Fiorentino, FI, Italy
[2] Univ Extremadura, Fac Vet, Dept Quim Organ, E-10071 Caceres, Spain
关键词
ugi reaction; isocyanides; 1,4-benzothiazepinones; aromatic nucleophilic substitution;
D O I
10.1016/j.tetlet.2005.09.071
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of 4,5-dihydro-1,4-benzothiazepin-3(2H)-ones 9 was prepared via Ugi 4-CC, S-N aliph, and S-N arom. This procedure, which resembles the well-known Hulme's and Zhu's protocols, allows a facile access to the above heterocyclic system. Further transformations of the cyclized products appear to be feasible. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:7977 / 7979
页数:3
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