Diterpenes and synthetic derivatives from Viguiera aspillioides with trypanomicidal activity

被引：42

作者：

daCosta, FB ^{[1
]}

Albuquerque, S ^{[1
]}

Vichnewski, W ^{[1
]}

机构：

[1] UNIV SAO PAULO,FAC CIENCIAS FARMACEUT,DEPT FIS & QUIM & CIENCIAS SAUDE,BR-14040903 RIBEIRAO PRET,SP,BRAZIL

来源：

PLANTA MEDICA | 1996年 / 62卷 / 06期

关键词：

D O I：

10.1055/s-2006-957971

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The dichloromethane extract of the tuberous roots of Viguiera aspillioides was tested in vitro against T. cruzi and then investigated in order to identify its active compounds, which were the known diterpenes (-)-ent-kaur-16-en-19-oic acid, (-)-trachyloban-19-oic acid, and (-)-kauran-16 alpha-ol. Synthetic derivatives of the acidic compounds were obtained and tested; one of them, (-)-kaur-16-en-19-ol, was also active. Their IC50 are given.

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页码：557 / 559

页数：3

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