A hydrogel for adhesion prevention: characterization and efficacy study in a rabbit uterus model

被引：13

作者：

Mueller, Sascha A. ^{[1
]}

Weis, Christine ^{[2
]}

Odermatt, Erich K. ^{[2
]}

Knaebel, Hanns-Peter ^{[2
]}

Wente, Moritz N. ^{[1
,2
]}

机构：

[1] Univ Heidelberg Hosp, Dept Gen Visceral & Transplantat Surg, Heidelberg, Germany

[2] Aesculap AG, Tuttlingen, Germany

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2011年 / 158卷 / 01期

关键词：

Adhesions; Adhesion formation; Hydrogel; Rabbit uterus horn model; HOSPITAL READMISSIONS; GEL; PROPHYLAXIS; ICODEXTRIN; REDUCTION; MEMBRANE; BARRIERS; SURGERY; SAFETY;

D O I：

10.1016/j.ejogrb.2010.11.008

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: Postoperative peritoneal adhesions following gynaecological surgery remain a clinically relevant problem. One approach to prevent adhesion formation is to apply physical barriers such as hydrogels. Study design: A physically crosslinked polyvinyl alcohol and carboxymethylcellulose (PVA/CMC) hydrogel (A-Part) was characterized in vitro. Three different traumatization methods were evaluated in a rabbit uterine study. To determine its anti-adhesion efficacy, the hydrogel was first tested in an in vivo pilot study and then in a larger trial to compare it with icodextrin 4% solution (Adept (R)) and controls. Results: Rheological measurements showed an increased elasticity of the hydrogel after freezing. In vivo experiments revealed a clear reduction in incidence, extent and severity of adhesions compared to the icodextrin 4% solution and the untreated control group. Conclusions: These results warrant further investigation of the PVA/CMC A-Part hydrogel in clinical trials focused on gynaecological procedures. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：67 / 71

页数：5