CROSSTALK CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

被引：77
作者：
Bak, Lasse K. [1 ]
Walls, Anne B. [1 ]
机构：
[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, 2 Univ Pk, DK-2100 Copenhagen, Denmark
来源：
JOURNAL OF PHYSIOLOGY-LONDON | 2018年 / 596卷 / 03期
关键词：
Lactate; Neuron; Astrocyte; FLUCTUATIONS; STIMULATION; GLYCOLYSIS; METABOLISM;
D O I：
10.1113/JP274945
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
[No abstract available]
引用
收藏
页码：351 / 353
页数：3
相关论文
共 22 条
[1]   Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons [J].
Bak, Lasse K. ;
Schousboe, Arne ;
Sonnewald, Ursula ;
Waagepetersen, Helle S. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2006, 26 (10) :1285-1297
[2]   Misconceptions Regarding Basic Thermodynamics and Enzyme Kinetics Have Led to Erroneous Conclusions Regarding the Metabolic Importance of Lactate Dehydrogenase Isoenzyme Expression [J].
Bak, Lasse K. ;
Schousboe, Arne .
JOURNAL OF NEUROSCIENCE RESEARCH, 2017, 95 (11) :2098-2102
[3]   Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels [J].
Bak, Lasse K. ;
Walls, Anne B. ;
Schousboe, Arne ;
Ring, Avi ;
Sonnewald, Ursula ;
Waagepetersen, Helle S. .
JOURNAL OF NEUROCHEMISTRY, 2009, 109 :87-93
[4]   Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain [J].
Bittar, PG ;
Charnay, Y ;
Pellerin, L ;
Bouras, C ;
Magistretti, PJ .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (06) :1079-1089
[5]   Lactate is a preferential oxidative energy substrate over glucose for neurons in culture [J].
Bouzier-Sore, AK ;
Voisin, P ;
Canioni, P ;
Magistretti, TJ ;
Pellerin, T .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (11) :1298-1306
[6]   Calcium Signaling in Brain Mitochondria INTERPLAY OF MALATE ASPARTATE NADH SHUTTLE AND CALCIUM UNIPORTER/MITOCHONDRIAL DEHYDROGENASE PATHWAYS [J].
Contreras, Laura ;
Satrustegui, Jorgina .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (11) :7091-7099
[7]   Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake [J].
Diaz-Garcia, Carlos Manlio ;
Mongeon, Rebecca ;
Lahmann, Carolina ;
Koveal, Dorothy ;
Zucker, Hannah ;
Yellen, Gary .
CELL METABOLISM, 2017, 26 (02) :361-+
[8]   Brain lactate metabolism: the discoveries and the controversies [J].
Dienel, Gerald A. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2012, 32 (07) :1107-1138
[9]   GLYCOGEN IN ASTROCYTES - POSSIBLE FUNCTION AS LACTATE SUPPLY FOR NEIGHBORING CELLS [J].
DRINGEN, R ;
GEBHARDT, R ;
HAMPRECHT, B .
BRAIN RESEARCH, 1993, 623 (02) :208-214
[10]   Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline [J].
Hertz, Leif ;
Gibbs, Marie E. ;
Dienel, Gerald A. .
FRONTIERS IN NEUROSCIENCE, 2014, 8
123