Toxicity of pyrrolizidine alkaloids to humans and ruminants

被引：156

作者：

Wiedenfeld, Helmut ^{[1
]}

Edgar, John ^{[2
]}

机构：

[1] Univ Bonn, Inst Pharmaceut, D-53121 Bonn, Germany

[2] CSIRO Food & Nutr Sci, N Ryde, NSW 2113, Australia

来源：

PHYTOCHEMISTRY REVIEWS | 2011年 / 10卷 / 01期

关键词：

Metabolic toxification; Detoxication; Poisoning in humans; Poisoning in ruminants; HEPATIC VENOOCCLUSIVE DISEASE; VENO-OCCLUSIVE DISEASE; DNA ADDUCT FORMATION; GROUNDSEL SENECIO-RIDDELLII; IN-OVINE RUMEN; LC-MS ANALYSIS; METABOLIC-ACTIVATION; TANSY RAGWORT; N-OXIDES; MEDICINAL-PLANTS;

D O I：

10.1007/s11101-010-9174-0

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

1,2-dehydro pyrrolizidine ester alkaloids (PA) are toxic for human and livestock. The PAs undergo a metabolic toxication process in the liver which is the first target organ for PA poisoning. World-wide many episodes of PA intoxications have been reported involving humans as well as ruminants. This intoxication is not only related to the amount and duration of the exposure to PAs but also to species, age and gender. Besides the metabolic toxification, detoxication processes are also important. The paper discusses the toxification and detoxication processes and gives an overview about PA poisoning cases in humans and ruminants.

引用

页码：137 / 151

页数：15

共 126 条

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