A Palladium-Catalyzed Vinylcyclopropane (3+2) Cycloaddition Approach to the Melodinus Alkaloids

被引：107
作者：
Goldberg, Alexander F. G. [1 ]
Stoltz, Brian M. [1 ]
机构：
[1] CALTECH, Div Chem & Chem Engn, Warren & Katharine Schlinger Lab Chem & Chem Engn, Pasadena, CA 91125 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 16期
基金：
加拿大自然科学与工程研究理事会;
关键词：
CRYSTAL-STRUCTURE; SCANDENS FORST; (+/-)-EPIMELOSCINE; (+/-)-MELOSCINE; (&)-SCANDINE; MELOSCINE;
D O I：
10.1021/ol2017615
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed (3 + 2) cycloaddition of a vinylcyclopropane and a beta-nitrostyrene is employed to rapidly assemble the cyclopentane core of the Melodinus alkaloids. The ABCD ring system of the natural product family is prepared In six steps from commercially available materials.
引用
收藏
页码：4474 / 4476
页数：3
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