The levels of NF-κB p50 and NF-κB p65 play a role in thyroid carcinoma malignancy in vivo

被引:22
作者
Le, Fei [1 ]
Zhang, Jing-Yu [2 ]
Liu, Wei [3 ]
Huang, Xian-Ming [1 ]
Luo, Wen-Zheng [1 ]
机构
[1] Jiangxi Canc Hosp, Dept Head & Neck Surg, 519 East Beijing Rd, Nanchang 330029, Jiangxi, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 1, Dept Head & Neck Surg, Nanchang, Jiangxi, Peoples R China
[3] Jiangxi Maternal & Child Hlth Care Hosp, Dept Reprod & Fertil, Nanchang, Jiangxi, Peoples R China
关键词
Thyroid cancer; nuclear factor-kappa B p50; nuclear factor-kappa B p65; immunohistochemistry; quantitative real-time reverse transcription-polymerase chain reaction; ACTIVATION;
D O I
10.1177/0300060518785846
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: To investigate the relationship between the levels of nuclear factor (NF)-kappa B p50 and NF-kappa B p65 and tumour characteristics in patients with thyroid carcinoma. Methods: This prospective study enrolled consecutive patients with thyroid carcinoma. Tumour samples were collected and the levels of NF-kappa B p50 and NF-kappa B p65 protein and mRNA were measured using immunohistochemistry and quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). Results: A total of 73 patients with thyroid carcinoma were included in the study (20 males; 53 females; mean +/- SD age, 44.8 +/- 12.7 years, range, 18-76 years). There were no significant differences in sex, age and pathological type between the NF-kappa B p50 positive group and the NF-kappa B p50 negative group, but tumour diameter and lymph node metastasis were significantly higher in the NF-kappa B p50 positive group compared with the NF-kappa B p50 negative group. Similar findings were observed for NF-kappa B p65. The levels of NF-kappa B p50 were positively correlated with NF-kappa B p65 in samples of thyroid carcinoma (r(s) = 0.653). Conclusion: The levels of NF-kappa B p50 and NF-kappa B p65 in samples of thyroid carcinoma were positively associated with tumour diameter and the presence of lymph node metastasis.
引用
收藏
页码:4092 / 4099
页数:8
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