Involvement of β2-microglobulin in CD69 expression on T cells

被引：0

作者：

Paczek, L ^{[1
]}

Czarkowska-Paczek, B ^{[1
]}

Korczak-Kowalska, G ^{[1
]}

Wierzbicki, P ^{[1
]}

Bartlomiejczyk, I ^{[1
]}

Górski, A ^{[1
]}

机构：

[1] Med Univ Warsaw, Inst Transplantat, PL-02006 Warsaw, Poland

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2001年 / 49卷 / 03期

关键词：

beta(2)-microglobulin; mononuclear cells; proliferation; CD69;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

beta (2)-Microglobulin (beta M-2) is the light chain of the class I HLA molecule. The serum level of beta M-2 is elevated in various diseases including lymphoma, inflammation, viral infections and chronic renal dysfunction. The present study addressed the possible influence of beta M-2 on T lymphocyte activation in vitro. Peripheral blood mononuclear cells from a group of 17 healthy subjects were examined. Stimulation with OKT3 and fibronectin in combination with 30 mg beta M-2/dl resulted in a two-fold increase of cell proliferation. A similar effect was observed when OKT3 and collagen I were applied as well as when OKT3 and collagen IV were used as costimulation to T cells. The CD69 expression, measured by flow cytometry was significantly enhanced above the control level (1.52 +/- 1.03% vs 33.21 +/- 20.26%, p <0.01, control group and 30 mg beta M-2/dl, respectively). Together, these observations suggest that beta M-2 may play a role in modulating lymphocyte proliferation, possibly through modification of the CD69 molecule.

引用

页码：239 / 242

页数：4

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