Screening for cognitive deficits in Parkinson's disease with the Parkinson neuropsychometric dementia assessment (PANDA) instrument

被引：182

作者：

Kalbe, Elke ^{[1
]}

Calabrese, Pasquale ^{[2
]}

Kohn, Nils ^{[1
]}

Hilker, Ruediger ^{[3
]}

Riedel, Oliver ^{[4
]}

Wittchen, Hans-Ulrich ^{[4
]}

Dodel, Richard ^{[5
]}

Otto, Joerg

Ebersbach, Georg

Kessler, Josef ^{[1
]}

机构：

[1] Univ Cologne, Dept Neurol, Univ Hosp, D-50937 Cologne, Germany

[2] Univ Clin, Dept Neurol, Bochum, Germany

[3] Goethe Univ Frankfurt, Dept Neurol, Frankfurt, Germany

[4] Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Dresden, Germany

[5] Univ Marburg, Dept Neurol, D-35032 Marburg, Germany

来源：

PARKINSONISM & RELATED DISORDERS | 2008年 / 14卷 / 02期

关键词：

Parkinson's disease; cognitive dysfunction; dementia; cognitive screening;

D O I：

10.1016/j.parkreldis.2007.06.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cognitive and affective dysfunctions are frequent but often neglected symptoms in Parkinson's disease (PD). We developed the screening tool Parkinson neuropsychometric dementia assessment (PANDA) with five cognitive tasks and a short depression questionnaire. Healthy subjects and patients without cognitive impairment (PD), mild cognitive disorder (PD-MCD), or dementia (PDD) were examined. The cognition part had a specificity of 91% and a sensitivity of 90%. for PDD and 77% for PDD plus PD-MCD patients. The mood questionnaire also had high sensitivity and specificity. We conclude that the PANDA is an economical, easy-to-use and sensitive tool to detect neuropsychological dysfunctions in PD patients in clinical practice. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：93 / 101

页数：9

共 47 条

[11] Mental object rotation in Parkinson's disease [J].

Crucian, GP ;

Barrett, AM ;

Burks, DW ;

Riestra, AR ;

Roth, HL ;

Schwartz, RL ;

Triggs, WJ ;

Bowers, D ;

Friedman, W ;

Greer, M ;

Heilman, KM .

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2003, 9 (07) :1078-1087

[12] SUBCORTICAL DEMENTIA - NEUROPSYCHOLOGY, NEUROPSYCHIATRY, AND PATHOPHYSIOLOGY [J].

CUMMINGS, JL .

BRITISH JOURNAL OF PSYCHIATRY, 1986, 149 :682-697

[13] Rivastigmine for dementia associated with Parkinson's disease [J].

Emre, M ;

Aarsland, D ;

Albanese, A ;

Byrne, EJ ;

Deuschl, G ;

De Deyn, PP ;

Durif, F ;

Kulisevsky, J ;

van Laar, T ;

Lees, A ;

Poewe, W ;

Robillard, A ;

Rosa, MM ;

Wolters, E ;

Quarg, P ;

Tekin, S ;

Lane, R .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (24) :2509-2518

[14] Dementia associated with Parkinson's disease [J].

Emre, M .

LANCET NEUROLOGY, 2003, 2 (04) :229-237

[15] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[16] Study of verbal working memory in patients with Parkinson's disease [J].

Gilbert, B ;

Belleville, S ;

Bherer, L ;

Chouinard, S .

NEUROPSYCHOLOGY, 2005, 19 (01) :106-114

[17] DEMENTIA AND COGNITIVE IMPAIRMENT IN PARKINSONS-DISEASE [J].

GIROTTI, F ;

SOLIVERI, P ;

CARELLA, F ;

PICCOLO, I ;

CAFFARRA, P ;

MUSICCO, M ;

CARACENI, T .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1988, 51 (12) :1498-1502

[18] Verbal fluency deficits in Parkinson's disease: A meta-analysis [J].

Henry, JD ;

Crawford, JR .

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2004, 10 (04) :608-622

[19] The relationship between executive function and verbal memory in Parkinson's disease [J].

Higginson, CI ;

King, DS ;

Levine, D ;

Wheelock, VL ;

Khamphay, NO ;

Sigvardt, KA .

BRAIN AND COGNITION, 2003, 52 (03) :343-352

[20] SPATIAL DISORIENTATION AS AN EARLY SYMPTOM OF PARKINSONS-DISEASE [J].

HOVESTADT, A ;

DEJONG, GJ ;

MEERWALDT, JD .

NEUROLOGY, 1987, 37 (03) :485-487

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