Screening for cognitive deficits in Parkinson's disease with the Parkinson neuropsychometric dementia assessment (PANDA) instrument

被引：182

作者：

Kalbe, Elke ^{[1
]}

Calabrese, Pasquale ^{[2
]}

Kohn, Nils ^{[1
]}

Hilker, Ruediger ^{[3
]}

Riedel, Oliver ^{[4
]}

Wittchen, Hans-Ulrich ^{[4
]}

Dodel, Richard ^{[5
]}

Otto, Joerg

Ebersbach, Georg

Kessler, Josef ^{[1
]}

机构：

[1] Univ Cologne, Dept Neurol, Univ Hosp, D-50937 Cologne, Germany

[2] Univ Clin, Dept Neurol, Bochum, Germany

[3] Goethe Univ Frankfurt, Dept Neurol, Frankfurt, Germany

[4] Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Dresden, Germany

[5] Univ Marburg, Dept Neurol, D-35032 Marburg, Germany

来源：

PARKINSONISM & RELATED DISORDERS | 2008年 / 14卷 / 02期

关键词：

Parkinson's disease; cognitive dysfunction; dementia; cognitive screening;

D O I：

10.1016/j.parkreldis.2007.06.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cognitive and affective dysfunctions are frequent but often neglected symptoms in Parkinson's disease (PD). We developed the screening tool Parkinson neuropsychometric dementia assessment (PANDA) with five cognitive tasks and a short depression questionnaire. Healthy subjects and patients without cognitive impairment (PD), mild cognitive disorder (PD-MCD), or dementia (PDD) were examined. The cognition part had a specificity of 91% and a sensitivity of 90%. for PDD and 77% for PDD plus PD-MCD patients. The mood questionnaire also had high sensitivity and specificity. We conclude that the PANDA is an economical, easy-to-use and sensitive tool to detect neuropsychological dysfunctions in PD patients in clinical practice. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：93 / 101

页数：9

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