Synthesis and characterization of graft copolymer of chitosan and polyethylene glycol

被引：7

作者：

Zhao, Yan ^{[1
]}

Sun, Yiyi ^{[1
]}

Zang, Zhihe ^{[1
]}

Xu, Xiaohong ^{[1
]}

Zhang, Zhonglin ^{[1
]}

Zhong, Ling ^{[1
]}

Zan, Wang ^{[1
]}

Zhao, Yan ^{[1
]}

Sun, Lin ^{[2
]}

机构：

[1] Chengdu Med Coll, Chengdu 610083, Sichuan, Peoples R China

[2] Sichuan Univ, W China Hosp, Chengdu 610041, Sichuan, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2011年 / 38卷 / 04期

关键词：

Chitosan; MPEG; Graft copolymer; Stealth nanoparticles; Carrier material; BLOCK-COPOLYMERS; PHYSICAL ENTRAPMENT; MICELLES; DELIVERY; DRUG; NANOPARTICLES; ADRIAMYCIN; DESIGN; MICELLIZATION; THERAPEUTICS;

D O I：

10.1007/s11033-010-0381-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MPEG was modified with 1,1'-carbonyldiimidazole, then the activated MPEG reacted with primary amino groups of chitosan. Synthesize the graft copolymer of chitosan and polyethylene glycol in two steps. The structure of the copolymer was characterized by FT-IR and 1H-NMR. It agrees with the PEG content of classical stealth nanoparticles materials. The X-ray diffraction and DSC analysis proved that the crystallinity of the copolymer increased. It is a promising material for the stealth nanoparticles. It is a potential new carrier for the drug delivery systems of long-circulation and solid carcinoma.

引用

页码：2455 / 2462

页数：8

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