The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

被引：598

作者：

Lo, Pui-Chi ^{[1
]}

Salome Rodriguez-Morgade, M. ^{[2
,3
]}

Pandey, Ravindra K. ^{[4
]}

Ng, Dennis K. P. ^{[5
]}

Torres, Tomas ^{[2
,3
,6
]}

Dumoulin, Fabienne ^{[7
]}

机构：

[1] City Univ Hong Kong, Dept Biomed Sci, Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

[2] Univ Autonoma Madrid, Dept Quim Organ, E-28049 Madrid, Spain

[3] Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, E-28049 Madrid, Spain

[4] Roswell Pk Canc Inst, Cell Stress Biol, Photodynam Therapy Ctr, Buffalo, NY USA

[5] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

[6] IMDEA Nanociencia, Madrid 28049, Spain

[7] Gebze Tech Univ, Chem Dept, TR-41400 Kocaeli, Turkey

来源：

CHEMICAL SOCIETY REVIEWS | 2020年 / 49卷 / 04期

关键词：

CONTAINING RUTHENIUM PHTHALOCYANINES; IN-VITRO; ZINC PHTHALOCYANINE; CONJUGATE; NANOPARTICLES; DESIGN; PHOTOPROPERTIES; DELIVERY;

D O I：

10.1039/c9cs00129h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.

引用

页码：1041 / 1056

页数：16

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